Prevalence of transfusion transmitted infections in children with inherited coagulation disorders

Authors

  • Urmila K. V. Department of Paediatrics, Pariyaram Medical College, Kannur, Kerala, India
  • Sarin S. M. Department of General Medicine, Pariyaram Medical College, Kannur, Kerala India
  • Mohammed M. T. P. Department of Paediatrics, Pariyaram Medical College, Kannur, Kerala, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20182985

Keywords:

Disorders, Hepatitis B, Hepatitis C, Inherited

Abstract

Background: Factor replacement and blood product transfusion are the main stay of treatment of inherited coagulation disorders. Even though interventions with these products have led to the decrease in morbidity and mortality of these patients, repeated use of these products especially before 1980s where the viral inactivation of factors and blood bank screening methods were not stringent, have led to the occurrence of transfusion transmitted diseases in haemophiliacs especially hepatitis C infection.

Methods: 50 children including adolescents under the age of 18 years with inherited coagulation disorders were screened for hepatitis B and C infection during 2 medical camps conducted at an interval of 6 months, blood samples and medical information were collected prospectively during these periods. The blood samples were tested for surrogate marker for hepatitis B and anti HCV using enzyme immunoassay.

Results: All the children screened were negative for hepatitis B and C markers.

Conclusions: The incidence of post transfusion hepatitis has dramatically decreased following stringent blood donor screening methods as well as availability of purified and recombinant factors. The current risk of transfusion transmitted infections in these patients are very low almost comparable with general population.

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Published

2018-08-24

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