A clinical study to determine the relationship between serum vitamin D levels and severity of asthma

Authors

  • Pragalatha kumar Department of Pediatrics, Indira Gandhi Institute of Child Health, Bengaluru, India
  • Aruna Gowdra Department of Biochemistry, Indira Gandhi Institute of Child Health, Bengaluru, India
  • Arathi Arathi Department of Pediatrics, Indira Gandhi Institute of Child Health, Bengaluru, India
  • Ananya Sampath Department of Pediatrics, Indira Gandhi Institute of Child Health, Bengaluru, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20172673

Keywords:

Children, Serum vitamin D levels, Severity of Asthma

Abstract

Background: Vitamin D deficiency has been rediscovered as a public health problem worldwide. Few studies have shown that vitamin D deficiency is associated with asthma severity. The objective of present work was to study the serum vitamin D levels and its relationship with asthma severity in children.

Methods: A prospective cohort study of 100 children with asthma between the age group of 5 to 15 years and age and sex matched 40 healthy controls who had come to Indira Gandhi Institute of Child Health, Bengaluru was done. These children’s serum vitamin D levels were estimated and correlated with asthma severity.

Results: A total of 100 children with asthma and 40 healthy age and sex matched controls were evaluated. The study group had lower vitamin D (34.95 ng/ml) levels as compared to the control group (57.94 ng/ml) which was statistically significant (p<0.05). 68.4% children had significantly low vitamin D levels and severe form of asthma (p value <0.001). There was also a marked rise in absolute eosinophil count in those who had low vitamin D levels (56.6%) (p-value <0.0001).

Conclusions: Vitamin D deficiency is an important risk factor for asthma severity. It modifies the immune system and reduces the inflammation. In the present study, low serum vitamin D levels were significantly correlated with severe form of asthma. There was a significant rise in the absolute eosinophil count in those who exhibited deficiency of vitamin D.  

References

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Published

2017-06-21

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Original Research Articles