Biochemical and microbiological evaluation of neonatal seizures

Authors

  • Bhaskar Reddy A. Assistant Professor, Department of Paediatrics, SVS Medical College, Mahabubnagar, Telangana
  • Ram Mohan G. Senior Resident, Department of Paediatrics, SVS Medical College, Mahabubnagar, Telangana

DOI:

https://doi.org/10.18203/2349-3291.ijcp20162246

Keywords:

Neonatal seizures, Biochemical, Microbiological

Abstract

Background:Neonatal seizure is a common neurological problem in the neonatal period. Neonatal seizures have always been a topic of interest because of their universal occurrence. A varied number of conditions are capable of causing seizures in the neonatal period. The highest incidence of neonatal seizure occurs during first 24 hours of life. The aim was to study biochemical and microbiological factors related with neonatal seizures.

Methods: The present study was conducted in the neonatology unit, department of pediatrics, SVS hospital and medical college. The study was done to assess the biochemical changes and microbilogical organisms implicated in neonatal seizures.

Results:In the present study, out of 1080 babies admitted to neonatology unit during the study period 100 developed seizures giving a hospital incidence of 9.25%. Etilogy in majority of cases of neonatal seizures was hypoxic ischemic encephalopathy (43%). Biochemical changes accounted for 17% of neonatal seizures. Meningitis accounted for 11% of neonatal seizures. The most common organism implicated in neonatal seizures was Escherichia coli (35%).

Conclusions:Biochemical abnormalities may significantly contribute to seizure activity and possibly correction of these abnormalities may play a significant role in seizure control. A biochemical work up is necessary for all cases of neonatal seizures. Appropriate treatment with antibiotics is essential. Examination of cerebrospinal fluid is essential work up in cases of neonatal seizures.

References

Rennie JM. In: Rennie JM, editor. Roberton’s Text Book of neonatology, 4th ed. Churchill Livingstone, Elsevier; 2005:1080,1087.

Zupanc ML. Neonatal seizures. Pediatr Clin N Am. 2004;51:961-78.

Mac DMG, Seshia MK, Mullet MD. In: Mac Donald MG, Seshia MK, Mullet MD, editors. Avery’s Neonatology: pathophysiology and management of newborn, 6th ed. Philadelphia, Lippincot Williams and Wilkins;2005:1386.

Mccabe BK, Silveira DC, Cilio MR. Reduced neurogenesis after neonatal seizure. J Neurosci. 2001;21(6):2094-103.

Levene M. The clinical conundrum of neonatal seizures. Arch Dis Childhood. 2002;86:75-7.

Kliegman RM, Behrman RE, Jenson HB, Stanton BF. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, editors. Nelson Textbook of Pediatrics, 18th ed. Saunders;2007:2471.

Volpe JJ. Neonatal seizures. current concepts and revised classification. Paediatr 1989;84:422-8.

Estan J, Hope PL. Unilateral neonatal cerebral infarction in full term infants. Arch Dis Childhood. 1997;76:88-93.

Kumar A, Gupta V, Kachhawaha JS. Biochemical abnormalities in neonatal seizures. Indian Pediatr. 1995;32:424-8.

Goldberg HJ. Neonatal convulsions: a ten year review. Arch Dis Childhood. 1982;57:633-5.

Ronnen GM, Penny S. The epidemiology of clinical neonatal seizues in znewfoundland; Canada: a five year cohort. Annals Neurol. 1995;38:518-9.

Airede IK. Neonatal seizures and a 2 year neurological outcome. J Trop Pediatr. 1991;37:313-7.

Andre M, Matisse M, Vert P. Neonatal seizures eccnt aspects. Neuropediatr. 1998;19;202-7.

Lein JM, Towers CV, Quiligan EJ. Term early onset neonatal seizures: obstetric characteristics; etiological classification and perinatal care. Obst Gyne. 1995;85:163-9.

Rose AL, Lombroso CT. A study of clinical, pathological and electroencephalographic features in 137 full term babies with a long term follow up. Pediatr. 1970;45:404-25.

Keen JH. Significance of hypocaleaemia in neonatal convulsions. Arch Dis Childh. 1969;44:356.

Gittleman IF, Pincus JB. Hypocalcemia occurring on the first day of life in mature and premature infants. Pediatr. 1956;18:721-9.

Tsang RC, Light IJ, Surtherland JM, Kleinman LI. Possible pathogenetic factors in neonatal hypocalcemia of permaturity. J Pediatr. 1973;82(3):423-9.

Sood A, Grover N, Sharma R. Biochemical abnormalities in neonatal seizures Indian J Pediatrics. 2003;70:221-4.

Bergman I, Painter MJ, Hirsch R. Outcome in neonates with convulsions treated in ICU. Annals Neurol. 1983;14:642-67.

Ortibus EL, Sum JM, Hahn JS. Predictive value of EEG for outcome and epilepsy following neonatal seizures. Electroencephalogr Clin Neurophysiol. 1996;98:175-85.

Downloads

Published

2016-12-21

Issue

Section

Original Research Articles