Identification and comparing the risk factors of new onset afebrile seizures with neuroimaging studies in children

Authors

  • Manikandan Paramasivam Department of Neonatology, Saveetha Medical College and Hospital, Saveetha Nagar, Thandalam, Chennai, Tamil Nadu, India
  • Maheshkumar Muthuraja Department of Pediatrics, Saveetha Medical College and Hospital, Saveetha Nagar, Thandalam, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20180516

Keywords:

Neuroimaging studies, New onset afebrile seizures, Risk factors

Abstract

Background: The study was aimed to identify the risk factors associated with new onset afebrile seizures by using neuroimaging techniques and comparing the same with neuroimaging studies in children of different age groups.

Methods: This prospective observational study included 65 children aged 1 month to 16 years with afebrile seizures, admitted to the tertiary care hospitals in Chennai during the period from July 2014 to August 2016. Neuroimaging was done in all the patients. The primary outcome measure was identification of risk factors/clinical variables, (if any) that could predict individuals at high or low risk for neuroimaging abnormalities.

Results: No statistical significant association was seen between differences in age group among children(p=0.127) and gender (p=0.185). Type of seizures, Number of seizure episodes and duration of seizure episodes seemed to be an important risk factor and a statistically significant association was observed between them and neuroimaging abnormalities with p values of 0.022, 0.008 and 0.001 respectively.

Conclusion: Our findings indicate that neuroimaging techniques were helpful in assessing the abnormalities related to new onset afebrile seizures

References

Bhavani G, Ramesh. Prevalence of neuroimaging abnormalities in children with new onset afebrile seizures in tertiary care hospital. J Evolution Med Dent Sci. 2016;5(48):2278-4802.

Alawneh HI, Bataineh HA. Urgent neuroimaging in children with first nonfebrile seizures. Middle Eat J Family Med. 2008;6(1)24-7.

Hirtz D, Ashwal S, Berg A, Bettis D, Camfield C, Camfield P, et al. Practice parameter: evaluating first nonfebrile seizure in children: report of the quality standards subcommittee of the American Academy of Neurology, The Child Neurology Society, and The American Epilepsy Society. Neurol. 2000;55(5):616-23.

Sharma S, Riviello JJ, Harper MB, Baskin MN. The role of emergent neuroimaging in children with new-onset afebrile seizures. Pediatr. 2003;111(1):1-5.

Krumholz A, Wiebe S, Gronseth G, Shinnar S, Levisohn P, Ting T, et al. Practice parameter: evaluating an apparent unprovoked first seizure in adults (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurol. 2007;69(21):1996-2007.

Saini N, Baghel A. Neuro-imaging abnormalities in children with first afebrile seizure. IOSR J Dent Med Sci. 2013;5(5):21-4.

Al-shamia R, Khaira AM, Elseida M, Ibrahima K, Al-Ahmada A, Elsetouhyb A, et al. Neuro-imaging evaluation after the first afebrile seizure in children: A retrospective observational study. Seizure. 2016;43:26-31.

Rasool A, Choh SA, Wani NA, Ahmad SM, Iqbal Q. Role of electroencephalogram and neuroimaging in first onset afebrile and complex febrile seizures in children from Kashmir. J Pediatr Neurosci. 2011;7:9-15.

Tavassoli A, Noormohamadi S. Factors related to abnormal neuroimaging in children with first unprovoked seizure. Iran J Child Neurol. 2011;5(1):15-20.

Garvey MA, Gaillard WD, Rusin JA, Ochsenschlager D, Weinstein S, Conry JA, et al. Emergency brain computed tomography in children with seizures: who is most likely to benefit? J Pediatr. 1998;133:664-9.

Dayan PS, Lillis K, Bennett J, Conners G, Bailey P, Callahan J, et al. Prevalence of and risk factors for intracranial abnormalities in unprovoked seizures. Pediatr. 2015;136(2):351-60.

Aprahamian N, Harper MB, Prabhu SP, Monuteaux MC, Sadiq Z, Torres A, et al. Pediatric first time non-febrile seizure with focal manifestations: is emergent imaging indicated? Seizure. 2014;23(9):740-5.

Downloads

Published

2018-02-22

Issue

Section

Original Research Articles