A study of lipid profile and carotid artery and abdominal aorta intima-media thickness in children with parental history of premature ischemic heart disease

Puneeth K. Pai, Nagendra K., Savitha Mysore Ramaraj


Background: Children born to parents with ischemic heart disease (IHD) can have dyslipidemia, a marker for IHD, detectable in early childhood and track to adulthood. Dyslipidemia along with factors like BMI, diet, sedentary activity increases risk of child developing IHD in adulthood. Early detection with non-invasive methods such as B mode ultrasound to measure carotid artery and abdominal aorta intima-media thickness can help in modification of these risk factors by suitable interventional strategies. The objectives of this study was to study the lipid profile and carotid artery and abdominal aorta intima-media thickness among children in the age group 5-18 years born to parents with history of premature IHD.

Methods: 23 children of parents with premature IHD and aged matched 28 controls without any family history of IHD were analyzed for cardiovascular risk factors: lipid profile and carotid and abdominal aorta intima-media thickness. The carotid intima-media thickness and abdominal aorta intima-media thickness was found by using B mode ultrasound.

Results: Mean abdominal aorta intima-media thickness was significantly higher among children with parental history of premature IHD than in those without it. Abdominal aorta intima-media thickness also showed significant positive correlation with total cholesterol. Carotid intima-media thickness showed positive correlation with the waist circumference. Mean total cholesterol levels (TC), low density lipoprotein cholesterol (LDL) and triglycerides (TG) were higher in children with family history as compared to children without family history but it was not statistically significant.

Conclusions: Abdominal aortic IMT is significantly more among children with parental history of premature ischemic heart disease compared to children without parental history of premature ischemic heart disease. Abdominal aortic intima-media thickness has significant association with total cholesterol while carotid intima-media thickness is significantly associated with waist circumference.


Abdominal aorta, Atherosclerosis, IMT, Ultrasound

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