Published: 2018-06-22

A retrospective study on the risk factors for retinopathy of prematurity in NICU of tertiary care hospital

Sundar K. C., Devi Meenakshi K., Aruna B. Patil


Background: Retinopathy of prematurity (ROP) affects developing retinal vasculature in premature infants. The risk factors for ROP are prematurity, low birth weight, oxygenation, respiratory distress, infection and frequent blood transfusion. Identification of risk factors leading to ROP may help in planning preventive strategies.

Methods: A retrospective analysis of records of preterm babies less than 34 weeks of gestation or birth weight less than 1750 grams and between 34 -36 weeks gestation or 1750-2000 grams birth weight associated with risk factors for ROP admitted to NICU of Kilpauk Medical college hospital from August 2015 to July 2016 were evaluated.

Results: Out of a total of 166 babies who were screened for ROP, 37 babies were detected to have ROP (22.3 %). Of these 20 (54%) were female and 17 (46%) were male. The mean birth weight of babies with ROP identified in our study was 1480 grams. The mean gestational age of babies with ROP was 32 weeks. By logistic regression analysis for mode of oxygen therapy as a risk factor for ROP it was found that prongs alone showed the strong risk factor towards ROP which was statistically significant. Sepsis, transfusion and shock requiring inotropes individually and statistical significantly contributed to the risk of ROP.

Conclusions: ROP was more common in babies <34 weeks. Sepsis, transfusion and shock requiring inotropes significantly contributed to the risk of ROP. Analysis of the mode of oxygen therapy showed that use of prongs significantly increased the risk of ROP.


Risk factors, Retinopathy of prematurity, Sepsis, Transfusion

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Olitsky SE, Hug D, Plummer LS, Stahl ED, Ariss MM, Lindquist TP. Disorders of vitreous and retina; In: Nelson textbook of pediatrics- 20th edition, Elsevier, Philadelphia;2016:3049.

Vedantham V. Retinopathy of prematurity screening in the Indian population: it’s time to set our own guidelines. Indian J Ophthalmol. 2007;55:329-30.

Abdel HAA, Hakeem, Mohamed GB, Othman MF. Retinopathy of prematurity: a study of prevalence and risk factors. Middle East Afr J Ophthalmol. 2012;19 (3):289-94.

Akkoyun I, Oto S, Yilmaz G, Gurakan B, Tarcan A, Anuk D, et al. Risk factors in the development of mild and severe retinopathy of prematurity. J AAPOS. 2006;10:449-53.

American Academy of Pediatrics. Screening examination of premature infants for retinopathy of prematurity. Pediatrics. 2001;108:809-11.

National Neonatology Forum, Clinical Practice Guidelines, Available at

Chen Y1, Li XX, Yin H, Gilbert C, Liang JH, Jiang YR, Zhao MW, Beijing ROP Survey Group. Risk factors for retinopathy of prematurity in six neonatal intensive care units in Beijing, China. Br J Ophthalmol. 2008 Mar;92(3):326-30.

Hungi B, Vinekar A, Datti N, Kariyappa P, Braganza S, Chinnaiah S et al. Retinopathy of Prematurity in a rural Neonatal Intensive Care Unit in South India--a prospective study. Indian J Pediatr. 2012 Jul;79(7):911-5.

Padhi TR, Jain L, Behera UC, Pradhan L. Retinopathy of prematurity profile and trend over the years: experience from a two-tier city in Eastern India. Indian Pediatr. 2016. Nov;53(2):76-79.

Chattopadhyay MP, Pradhan A, Singh R, Datta S. Incidence and Risk Factors for Retinopathy of Prematurity in Neonates, Indian Pediatr. 2015;52:157-8.

Shah PK, Narendran V, Kalpana N, Gilbert C. Severe retinopathy of prematurity in big babies in India: history repeating itself?. Indian J Pediatr. 2009 Aug;76(8):801.

Dutta S, Raghuveer T, Vinekar A, Dogra MR. Can we stop the current epidemic of blindness from Retinopathy of Prematurity?. Indian pediatrics. 2016 Nov;53(2):80-84.

Chaudhari S, Patwardhan V, Vaidya U, Kadam S, Kamat A. Retinopathy of prematurity in a tertiary care center--incidence, risk factors and outcome, Indian Pediatr. 2009 Mar;46(3):219-24.

Sabzehei MK, Afjeh SA, Dastjani Farahani A, Shamshiri AR, Esmaili F. Retinopathy of prematurity: incidence, risk factors, and outcome. Arch Iran Med. 2013 Sep;16(9):507-12.

15. Akkoyun I, Oto S, Yilmaz G, Gurakan B, Tarcan A, Anuk D, et al. Risk factors in the development of mild and severe retinopathy of prematurity. J AAPOS. 2006;10:449-53.

Vinekar A, Dogra MR, Sangtam T, Narang A, Gupta A. Retinopathy of prematurity in Asian Indian babies weighing greater than 1250 grams at birth: Ten year data from a tertiary care center in a developing country. Indian J Ophthalmol. 2007;55:331-6.