DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20185189

Utility of cord blood albumin as a predictor of significant neonatal jaundice in healthy term newborns

Yogesh N. Parikh, Jay C. Ghetia, Aarti M. Makawana

Abstract


Background: The aim is to study the association between cord blood albumin level and subsequent development of significant neonatal jaundice (NNJ) in healthy term newborns.

Methods: A prospective study was conducted on 106 term healthy neonates. Genders, gestational age, mode of delivery were taken into consideration. It was ascertained that there was no other risk factor for hyperbilirubinemia amongst the neonates. The neonates were divided into two groups based on cord blood albumin level of <3.2gm/dl and >3.2gm/dl.

Results: Out of the 106 babies included in the study, 44 babies were under group A (<3.2mg/dl) and 62 babies were under group B(>3.2mg/dl). 24 babies (55%) in group A and 16 babies (26%) in group B developed clinical icterus of which 16(66.6%) in group A and 4(25%) in group B required phototherapy. There was no significant difference between the cases who did and who did not develop significant neonatal jaundice with respect to various factor such as type of delivery, gender and meconium stain liquor.

Conclusions: Cord albumin levels help to determine and predict the possibility of hyperbilirubinemia among neonates. Hence this can help to identify the at-risk neonates. So routine determination of cord albumin can be advocated to keep a track on at risk neonates.


Keywords


Cord blood albumin, Hyperbilirubinemia, Meconium, Neonatal jaundice

Full Text:

PDF

References


Sgro M, Campbell D, Shah V. Incidence and causes of severe neonatal hyperbilirubinemia in Canada. Canadian Med Ass J. 2006;175(6):587-90.

Maisels MJ, Newman TB. Kernicterus in otherwise healthy, breast-fed term newborns. Pediatr. 1995;96(4):730-3.

Lee KS, Perlman M, Ballantyne M, Elliott I, To T. Ass between duration of neonatal hospital stay and readmission rate. J Pediatr. 1995;127(5):758-66.

Agarwal R, Kaushal M, Aggarwal R, Paul VK, Deorari AK. Early neonatal hyperbilirubinemia using first day serum bilirubin level. Indian Pediatr. 2002;39(8):724-30.

Maisels MJ, Kring E. Length of stay, jaundice, and hospital readmission. Pediatr. 1998;101(6):995-8.

American Academy of Pediatrics. Practice parameter: management of hyperbilirubinemia in the healthy term newborn. Pediatr. 1994;94:558-65.

Carty EM, Bradley CF. A randomized, controlled evaluation of early postpartum hospital discharge. Birth. 1990;17(4):199-204.

Sahu S, Abraham R, John J, Mathew MA, Res M. Cord blood albumin as a predictor of neonatal jaundice. Int J Biol Med Res. 2011;2(1):436-8.

Trivedi DJ, Markande DM, Vidya BU, Bhat M, Hegde PR. Cord serum bilirubin and albumin in neonatal hyperbilirubinemia. Int J Int Sci Inn Tech Sec A. 2013;2(2):39-42.

Bunt JE, Rietveld T, Schierbeek H, Wattimena JD, Zimmermann LJ, van Goudoever JB. Albumin synthesis in preterm infants on the first day of life studied with [1-13C] leucine. Am J Physiol Gastrointest Liver Physiol. 2007;292(4):G1157-61.

Taks A, Vilhekar K, Jain M, Zade P, Atkari S, Verkey S. Prediction of the development of neonatal hyperbilirubinemia by increased umbilical cord blood bilirubin. Current Pediatr Res. 2005;9(1).

Sun G, Wang YL, Liang JF, Du LZ. Predictive value of umbilical cord blood bilirubin level for subsequent neonatal jaundice. Z Safflower Paediatr J Chin J Pediatr. 2007;45(11):848-52.