DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20184303

A study on clinical profile of neonatal seizures in newborn babies born in Government Mohan Kumara Mangalam Medical College Hospital, India

Amudhadevi S., Kanchana P.

Abstract


Background: Seizures represent the most distinctive signal of neurological disease in the newborn period. The convulsive phenomena are the most frequent of the overt manifestations of neonatal neurological disorders. This study was aimed at providing a clear picture regarding the epidemiology, etiology, onset, types and mortality of neonatal convulsions in our hospital. This study was carried to assess the incidence, types of Neonatal convulsions, etiology, time of onset and its relationship with the etiology and to determine the mortality associated with neonatal convulsions.

Methods: This study was carried out in Government Mohan Kumaramangalam Medical College Hospital in June 2016 - May 2017.The Study Population is Newborn babies born in our hospital and admitted in Neonatal Intensive Care Unit. Babies born in other hospitals or at home with neonatal convulsions were excluded from the study. A detailed history was elicited for all recruited babies and was thoroughly examined. The baby’s clinical progression was closely monitored, and relevant investigations done. Data were entered in Microsoft Excel and analyzed in SPSS version 12.

Results: There were 1385 neonatal cases admitted in the newborn ward in Govt. Mohan Kumaramangalam Medical College Hospital, Salem during the period of 12 months from June 2016 to May 2017.  Of these, 104 neonates had convulsions. There were 4102 total live births in this period for 12 months from June 2010 to May 2011.  Of these, 104 neonates had convulsions. So, the incidence of neonatal convulsions is 2.5%.

Conclusions: Since birth asphyxia is the commonest cause of neonatal convulsions, improvement in antenatal, perinatal care with early identification of high-risk mothers will reduce the incidence of birth asphyxia and thereby reduce the incidence of neonatal convulsions. Subtle seizures are the commonest type of clinical seizures; therefore, careful observation of at risk newborns is necessary.


Keywords


Birth Asphyxia, Neonatal convulsions, Tertiary care hospital

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References


Lanska MJ, Lanska DJ. Neonatal seizures in the United States: results of the national hospital discharge survey. Neuroepidemiol. 1996;15(3):117-25.

Lanska MJ, Lanska DJ, Baumann RJ, Kryscio RJ. A population-based study of neonatal seizures in Fayette County, Kentucky. Neurol. 1995;45(4):724-32.

Ronen GM, Penney S, Andrews W. The epidemiology of clinical neonatal seizures in Newfoundland: a population-based study. J Pediatr. 1999;134(1):71-5.

Holden KR, Mellits ED, Freeman JM. Neonatal seizures I. Correlation of prenatal and perinatal events with outcomes. Pediatr. 1982;70(2):165-76.

Brown JK, Cockburn F. Clinical and chemical correlates in neonatal convulsions. Lancet. 1972;1:135-9.

Ravneet S. A clinical study of seizures in neonates. In: Shah NK, Agrawal R,Yewale V, editors. Abstracts XXX National Conference of the Indian Academy of Pediatrics.2003:209-10.

Digra SK, Gupta A. Prevalence of seizures in hospitalized neonates. JK Sci. 2007;9(1):27-9.

Saliba RM, Annegers FJ, Waller DK, Tyson JE, Mizrahi EM. Risk factors for neonatal seizures: a population-based study, Harris County, Texas. Am J Epidemiol. 2001;154(1):14-20.

Mahaveer L, Vilhekar KY, Pushpa C. Clinico-biochemical profile of Neonatal seizures in a rural medical college. In: Fernandez A, Dadhich JP, Suluja S, Editors, Abstracts, XXIII Annual Convention of National Neonatology Forum; 2003:121-122.

Moayedi AR, Zakeri S, Moayedi F. Neonatal seizure: etiology and type. Iran J Child Neurol. 2007:23-6.

Myles TD, Santoloya J. Maternal and neonatal outcomes in patients with a prolonged Second stage of labour. Obsterics and Gynecol. 2003;102:52-8.

Taksande AM, Vilhekar K, Jain M, Lakra M. Clinico-biochemical profile of neonatal seizures. Indian J Pediatr. 1995;52:424-7.

Philip BJ. Prediction of outcome based on clinical seizures type in newborn infants. J Pediatr. 2002;140(6):707-12.

Holanda MR, Melo ÁN. Comparative clinical study of preterm and full-term newborn neonatal seizures. Arquivos de neuro-psiquiatria. 2006;64(1):45-50.

Arun S. Clinical profile of seizures in neonatal intensive care unit. In Abstracts, XXIII Annual Convention of National Neonatology Forum 2003;18:109-111.

Finer NN, Robertson CM, Richards RT, Pinnell LE, Peters KL. Hypoxic-ischemic encephalopathy in term neonates: perinatal factors and outcome. J Pediatr. 1981;98(1):112-7.

Lawrence LD, Leinz GA, Rosita PS. Treatment of neonatal hypoglycemia with continuous intravenous infusion. J Paediatr. 1977:91(5):779-82.

Cockburn F, Brown JK, Belton NR, Forfar JO. Neonatal convulsions associated with primary disturbance of calcium, phosphorus, and magnesium metabolism. Arch Dis Childhood. 1973;48(2):99.

Tushar PB, Rekha UH, Ruchi NN. C-reative protein and diagnosis of neonatal meningitis. In: Fernandez A, Dadhich JP, Saluja S, Editors. Abstracts, XXIII Annual Convention of National Neonatology Forum; 2003;18(21):157-8.