Prevalence of Hepatitis C Virus (HCV) infection among jaundiced children

Authors

  • Nazir Ahmed Department of Pediatrics, SKIMS Medical College Bemina, Srinagar, Jammu and Kashmir, India
  • Mohd Irshad Consultant Pediatrics, Jammu and Kashmir Health Services, India
  • Mohd Ashraf Department of Pediatrics, Government Medical College, Srinagar, Jammu and Kashmir, India
  • Yasmeena Akhter Department of Anatomy, Government Medical College, Srinagar, Jammu and Kashmir, India
  • Gh Rasool Wani Department of Pediatrics, Government Medical College, Srinagar, Jammu and Kashmir, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20184294

Keywords:

Hepatitis C, Infection, Prevalence

Abstract

Background: Viral hepatitis continues to be major public health problem in both developing and developed countries. Acute hepatitis C virus (HCV) infection tends to be mild and insidious in onset, with long term health and economic implications. The aim of the study was to determine prevalence of HC virus infection in hospitalized jaundiced children of Kashmir.

Methods: This hospital based prospective study was conducted in the department of pediatric Govt Medical Collage Srinagar over a period of 1year from October 2007 to September 2008. A total of 100 patients were included in this study. Oral questionnaire pertaining to various aspects of HCV virus infection was administered and serum sample of all patients were analyzed for anti-hepatitis C virus antibody by ELISA method using Zhongshan HCV ELISA kit china. Diagnosis was confirmed in positive cases by PCR for HCV RNA.

Results: Only two patients out of 100 patients were positive for hepatitis C virus antibody, both patients were admitted as chronic liver disease (CLD), one being 15 years old male and other 9 years old female. Seventy-four patients were positive for Hepatitis A, IgM antibody, out of which 8 patients had fulminant hepatic failure and one patient was HBsAg positive.

Conclusions: This study highlights the daunting prevalence of HCV infection in our setup and implicates necessity for raising the awareness and screening of HCV-high risk individuals to decrease mortality and morbidity associated with Hepatitis C virus infection.

References

Jensen MK, Balistreri WF. Viral hepatitis. In: Kliegman RM, Stanton BF, St Geme JW, Schor NF. Nelson textbook of pediatrics. Elsevier health; 2015:1942-1953.

Mushtaq M, Alam S, Shukla I, Ali M. Prevalence of hepatitis C virus infection among children with liver disease. Curr Pediatr Res. 2009;13(1).

Khan MSA, Khalid M, Ayub N, Javed M. Seroprevalence and risk factors of Hepatitis C virus (HCV) in Mardan NWFP. Rawal Med J 2004;29(2):57-60.

Bigna JJ, Amougou MA, Asangbeh SL, Kenne AM, Nansseu JR. Seroprevalence of hepatitis C virus infection in Cameroon: a systematic review and meta-analysis. BMJ Open. 2017;7(8):e015748..

Bhattacharya S, Badrinath S, Hamide A, Sujatha S. Seroprevalence of hepatitis C virus in a hospital based general population in South India. Indian J Med Microbiol. 2003;21:43-5.

Al-Faleh FZ, Ayoola EA, Al-Jeffry M, Al-Rashed R, Al-Mofarreh M, Arif M, et al. Prevalence of antibody to hepatitis C virus among Arabian children. A community-based study. Hepatol. 1991;14(2):215-18.

Parker SP, Khan HI, Cubitt WD. Detection of antibodies to hepatitis C virus in dried blood spot samples and their offspring in Lahore, Pakistan. J Clin Micro. 1999;37(6):2061-3.

Jafri W, Jafri N, Yakoob J, Islam M, Tirmizi SFA, Jafer T et al. Hepatitis B and C: prevalence and risk factors associated with seropositivity among children in Karachi Pakistan. BMC Infect Dis. 2006,6:101.

Lee WS, Ng KP. Seroprevalence of anti-HCV in an urban child population: A preliminary study from Kuala Lumpur. Singapore Med J. 2001;42:100-1.

Hazra SC, Chaterjee S, Gupta SD, Chaudhuri U, Jana CK, Neogi DK. Changing scenario of transfusion related viral infections. J Assoc Physicians India. 2002;50:879-81.

Amarapurkar D, Dhorda M, Kirpalani A, Amarapurkar A, Kankonkar S. Prevalence of hepatitis C genotypes in Indian patients and their clinical significance. J Assoc Physicians India. 2001;49:983-5.

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Published

2018-10-22

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Original Research Articles