DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20184696

Antibiotic susceptibility among under-fives with severe pneumonia: a prospective study

Loganathan Palanivel, Chidambaranathan Sivaprakasam, Logesvar Palanisamy

Abstract


Background: In underdeveloped countries, lower respiratory tract infection (LRTI) remains the leading cause of under-five mortality. Judicious use of antibiotics prevents the emergence of multidrug resistant organisms, but appropriate selection is vital in the child requiring intensive care.

Methods: The study in conducted prospectively in the paediatric wards and intensive care unit, Rajah Muthiah Medical College and Hospital, Chidambaram. Fifty children were enrolled in the study using simple random sampling. Data regarding the demographic details, mean duration of stay, antibiotics given, immunisation status, intensive care unit admission and complications were collected. Statistical analysis is done using the Microsoft excel 2010.

Results: The complications (n=3) is more among the female children (n=2) belonging to the age group one to two years (n=2) with mean duration of stay of more than seven days (n=2) and non-immunized for age children (n=3).

Conclusions: The gram positive and atypical pneumonia in Chidambaram is found to be sensitive to aminopenicillin with penicillinase resistant penicillin and macrolide respectively.


Keywords


Antibiotic resistance, Bacterial infections, Lower respiratory tract infection, Under-five

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References


Liu P, Xu M, He L, Su L, Wang A, Fu P, et al. Epidemiology of respiratory pathogens in children with lower respiratory tract infections in Shanghai, China, from 2013 to 2015. Jpn J Infect Dis. 2018;71(1):39-44.

Mathew JL, Patwari AK, Gupta P, Shah D, Gera T, Gogia S, et al. Acute respiratory infection and pneumonia in India: a systematic review of literature for advocacy and action: UNICEF-PHFI series on newborn and child health, India. Indian Pediatr. 2011;48(3):191.

Ning G, Wang X, Wu D, Yin Z, Li Y, Wang H, et al. The etiology of community-acquired pneumonia among children under 5 years of age in mainland China, 2001-2015: A systematic review. Hum Vaccines Immunother. 2017;13(11):2742-50.

De Luca M, Donà D, Montagnani C, Vecchio A Lo, Romanengo M, Tagliabue C, et al. Antibiotic prescriptions and prophylaxis in Italian children. Is it time to change? Data from the ARPEC project. PLoS One. 2016;11(5):e0154662.

Deb SK. Acute respiratory disease survey in Tripura in case of children below five years of age. J Indian Med Assoc. 1998;96(4):111-6.

Qazi SA, Rehman GN, Khan MA. Standard management of acute respiratory infections in a children’s hospital in Pakistan: Impact on antibiotic use and case fatality. Bull World Health Organ. 1996;74(5):501-7.

Jacobs MR. Worldwide trends in antimicrobial resistance among common respiratory tract pathogens in children. Pediatr Infect Dis J. 2003;22(8):S109-19.

Mtango EDE, Neuvians D. Acute respiratory infections in children under five years. Control project in Bagamoyo District, Tanzania. Trans R Soc Trop Med Hyg. 1986;80(6):851-8.

Fendrick AM, Saint S, Brook I, Jacobs MR, Pelton S, Sethi S. Diagnosis and treatment of upper respiratory tract infections in the primary care setting. Clin Ther. 2001;23(10):1683-706.

Cirafesi WV, Peterman GW. Christ in hippolytus’s De Christo et Antichristo: a response to Michael F. Bird and Michael R. Whitenton. New Testam Stud. 2011;57(4):594-603.

Appelbaum PC. Bacterial resistance in the new millennium. Its impact on antibiotic selection for respiratory tract infections. Postgrad Med. 2000;108(7 Suppl Contemporaty):5-16.

Abu NA, Nor FM, Mohamad M, Abidin ASZ, Adnan A, Nor NSM, et al. Community-acquired Bacteremia in paediatrics: Epidemiology, aetiology and patterns of antimicrobial resistance in a tertiary care centre, Malaysia. Med J Malaysia. 2016;71(3):117-21.

Shaheen MH, Siddiqui MI, Jokhdar HA, Hassan-Hussein A, Garout MA, Hafiz SM, et al. Prescribing patterns for acute respiratory infections in children in primary health care centers, Makkah Al Mukarramah, Saudi Arabia. J Epidemiol Glob Health. 2017.

Shann F, Hart K, Thomas D. Acute lower respiratory tract infections in children: Possible criteria for selection of patients for antibiotic therapy and hospital admission. Bull World Health Organ. 1984;62(5):749-53.