Primary antiphospholipid syndrome in children: experience from two tertiary centres in South India

Authors

  • Mahesh Janarthanan Department of Pediatric Rheumatology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India http://orcid.org/0000-0002-6986-7978
  • Dhaarani Jayaraman Department of Pediatric Hematology and Oncology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India
  • Julius Scott Department of Pediatric Hematology and Oncology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India
  • M. S. Latha Department of Pediatric Hematology and Oncology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India
  • Saravanan Margabandhu Department of Pediatrics, Apollo Children’s Hospitals, Chennai, Tamil Nadu, India
  • Chitra Sundaramoorthy Department of Pediatrics, Apollo Children’s Hospitals, Chennai, Tamil Nadu, India
  • S. Srinivas Department of Pediatrics, Apollo Children’s Hospitals, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20190070

Keywords:

Children, Primary antiphospholipid syndrome, Thrombosis

Abstract

Background: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by the presence of episodes of vascular thrombosis, recurrent fetal loss and other clinical features in the presence of antiphospholipid antibodies. The aim of the study was to analyze the clinical manifestations and immunologic profile of children presenting with APS.

Methods: Authors did a retrospective case record study of patients admitted with thrombotic events between September 2013 and August 2018 and identified patients with positive antiphospholipid antibodies. Children who had clinical features of active lupus were not included.

Results: The clinical and immunologic profile of 7 pediatric patients presenting with APS over 5 years from 2013 to 2018 were analysed. Symptoms secondary to vascular thrombosis were limb swelling, stroke, gangrene of toes and Budd Chiari syndrome.

Conclusions:APS though rare should be considered in the differential diagnosis of children presenting with thrombotic events. They need long term anticoagulants to prevent further episodes.

 

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Published

2019-02-23

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Original Research Articles