DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20163690

A study of association between vitamin d deficiency in sepsis

Nishat Ahmed, Vikram Yadav, Rajendra Kumar Soni, Niranjan Nagaraj, Pramod Kumar Berwal, Gunshyam Singh Sengar

Abstract


Background:Vitamin D is a fat-soluble steroid hormone that contributes to the maintenance of normal calcium homeostasis and skeletal mineralization the aims of this study is to evaluate vitamin D levels in pediatric patients admitted in the intensive care unit with sepsis.

Methods: Fifty children between 1 year to 12 years of age with systemic inflammatory response syndrome (SIRS) with suspected or proven sepsis, admitted in PICU were included for the study. Blood was drawn at the time of admission on the first day of hospital stay for measurement of 25-hydroxyvitamin D (25-OHD) levels.

Results:Forty two (84%) patients out of 50 patients had vitamin D levels < 30ng/ml and only 8 patients had vitamin D >30 ng/ml. This was statistically significant as the p value was <0.05.

Conclusions:Lower 25-OHD levels are associated with sepsis. The multiple functions of vitamin D in the immune system’s response to infection suggest it may be an integral component in combating sepsis.  


Keywords


Bikaner, Immune system, Sepsis, Vitamin D

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References


Luca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004;80:1689-96.

Clancy N, Onwuneme C, Carroll A, Mccarthy R, Mckenna MJ, Murphy N .Vitamin D and neonatal immune function. J Matern Fetal Neonatal Med. 2013;26:639-46.

Kempker JA, Han JE, Tangpricha V, Ziegler TR, Martin GS. Vitamin D and sepsis: an emerging relationship. Dermatoendocrinol. 2012;4:101-8.

Liu PT, Stenger S, Li H. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;311:1770-3.

Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25 hydroxyvitamin D level and upper respiratory tract infections in the third national health and nutrition examination survey. Arch Intern Med. 2009;169:384-90.

Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in school children. Am J Clin Nutr. 2010;91:1255-60.

Equils O, Naiki Y, Shapiro AM. 1, 25-Dihydroxyvitamin D3 inhibits lipopolysaccharide induced immune activation of human endothelial cells. Clin Exp Immunol. 2006;143:58-64.

Møller S, Laigaard F, Olgaard K, Hemmingsen C. Effect of 1,25-dihydroxy-vitamin D3 in experimental sepsis. Int J Med Sci. 2007;4:190-5.

Jeng L, Yamshchikov AV, Judd SE, Blumberg HM, Martin GS. Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J Transl Med. 2009;7:28.

Ginde AA, Camargo CA, Shapiro NI. Vitamin D insufficiency and sepsis severity in emergency department patients with suspected infection. Acad Emerg Med. 2011;18:551-4.

Bachhel R, Singh NR, Sidhu JS. Prevalence of vitamin D deficiency in north-west Punjab population: A cross sectional study. Inj J App Basic Med Res. 2015;5:7-11.

Lee P, Eisman JA, Center JR. Vitamin D deficiency in critically ill patients. N Engl J Med. 2009;360:1912-4.

Azim A, Ahmed A, Yadav S, Baronia AK, Gurjar M et al. Prevalence of vitamin D deficiency in critically ill patients and its influence on outcome: experience from a tertiary care centre in North India (an observational study). J Intensive Care. 2003;1(1):14.

Flynn L, Zimmerman LH, Mcnorton K, Dolman M, Tyburski J, Baylor A, et al. Effects of vitamin D deficiency in critically ill surgical patients. Am J Surg. 2012;203:379-82.

Satheesh P, Verma S, Singhi S, Bansal A. Prevalence of vitamin D deficiency among children with sepsis, its assocaiton with sepsis severity and its outcome in a pediatric IUC. Critical Care. 2013;17(4):35.