DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20190436

Prevalence of HIV infection among children with TB and correlation of CD4 cell count level with types of TB

Sivabalan T., Rajkumar G.

Abstract


Background: Tuberculosis (TB) is the second most common cause of death from infectious diseases at the global level, being second only to HIV/AIDS. The present study has been undertaken to find out the prevalence of HIV infection among children with TB and correlation of CD4 cell count level with different types of TB.

Methods: This cross-sectional study was carried out in children below 12 years who were diagnosed as having TB, using the modified Kenneth Jones criteria (742 TB infected children) between 2008 and 2010. Descriptive statistics were used to calculate the frequency, mean, median and standard deviation. The linear trend of proportions and trend of chi-square was used to find out the test of association.

Results: The HIV prevalence rate among children with Tuberculosis was 9.7%. In TB/HIV coinfection, Pulmonary TB was 44 (61.1%), lymph node TB was 22 (30.6%), Central Nervous System TB was 4 (5.6%), abdominal TB was 1 (1.4%) and spine TB was (1.4%). Pulmonary TB was the most common type is the not significant, mild and advanced grade of immune suppression. CNS tuberculosis was the most common type in the severe grade of immune suppression. CNS TB occurred more commonly in children more than 60 months of age. Lymph node TB is the commonest type of tuberculosis in children with HIV coinfection less than 35 months of age.

Conclusions: The prevalence of HIV among tuberculosis children was 9.7%. This prevalence rate indicates the need for routine screening of all newly diagnosed tuberculous children for HIV coinfection.

 


Keywords


Coinfection, HIV, Prevalence, Screening, Tuberculosis

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References


India TB Report 2018. New Delhi: Directorate General of Health Services, Ministry of Health and Family Welfare; 2018:7-11. Available at: http://file:///C:/Users/Archana/Downloads/6250311444TB%20India%20Report%202018.pdf. 2018.

Newton SM, Brent AJ, Anderson S, Whittaker E, Kampmann B. Paediatric tuberculosis. Lancet Infect Dis. 2008;8(8):498-510.

Marais BJ, Schaaf HS. Tuberculosis in children. Cold Spring Harb Perspect Med. 2014;4(9):a017855.

Sandhu GK. Tuberculosis: current situation, challenges and overview of its control programs in India. J Glob Infect Dis. 2011;3(2):143-50.

Yin DE, Warshaw MG, Miller WC, Castro H, Fiscus SA, Harper LM, et al. Using CD4 percentage and age to optimize pediatric antiretroviral therapy initiation. Pediatr. 2014;134(4):e1104-e16.

Guideliness for HIV care and treatment in infants and children by IAP and NACO Nov 2006. Available at: http://www.iapsmgc.org/userfiles/4Guidelines_for_HIV_care_and_treatment_in_Infants_and_children.pdf.

WHO. Towards universal access: scaling up priority HIV/AIDS interventions in the health sector. Progress report. 2007. Available at: http://www.who.int/hiv/mediacentre/universal_access_progress_report_en.pdf.

Flick RJ, Kim MH, Simon K, Munthali A, Hosseinipour MC, Rosenberg NE, et al. Burden of disease and risk factors for death among children treated for tuberculosis in Malawi. Int J Tuberc Lung Dis. 2016;20(8):1046-54.

Ramzan M, Ali SM, Malik A, Zaka-ur-Rab Z, Shahab T. Frequency of HIV infection amongst children with disseminated tuberculosis and tuberculous meningitis in Aligarh (North India)-a low HIV prevalence area. J Coll Physicians Surg Pak. 2009;19:566-9.

Hussain T, Sinha S, Kulshreshtha KK, Yadav VS, Sharma P, Sengupta U, et al. Seroprevalence of HIV infection among tuberculosis patients in Agra, India--a hospital-based study. Tuberculosis (Edinb). 2006;86(1):54-9.

Parthasarathy P, Mittal SK, Sharma VK. Prevalence of pediatric HIV in New Delhi. Indian J Pediatr 2006;73(3):205-7.

Jain SK, Ordonez A, Kinikar A, Gupte N, Thakar M, Mave V, et al. Pediatric tuberculosis in young children in India: a prospective study. Biomed Res Int. 2013;2013:783698.

Antonucci G, Girardi E, Raviglione MC, Ippolito G. Risk factors for tuberculosis in HIV-infected persons. A prospective cohort study. The Gruppo Italiano di Studio Tubercolosi e AIDS (GISTA). JAMA. 1995;274(2):143-8.

Gupta RK, Lawn SD, Bekker LG, Caldwell J, Kaplan R, Wood R. Impact of human immunodeficiency virus and CD4 count on tuberculosis diagnosis: analysis of city-wide data from Cape Town, South Africa. Int J Tuberc Lung Dis. 2013;17(8):1014-22.