DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20191008

Mean platelet volume (MPV) as a diagnostic marker in neonatal sepsis

Prathyusha ., Shreekrishna G. N., Sinchana Bhat, Sahana P.

Abstract


Background: Neonatal sepsis is a frequent and important cause of morbidity and mortality which accounts for one quarter of neonatal deaths. There are very few studies done in India to evaluate the role of MPV as diagnostic marker of neonatal sepsis.

Methods: Prospective case control study in a tertiary care hospital. Neonates > 30 weeks gestation admitted to neonatal intensive care unit during the study period of 1 year with clinically suspected were included in the study. Neonates with Septic screen positive and culture positive sepsis were included in group A and normal neonates were included in Group B. MPV was done for all the subjects and values more than 10.2fl was considered positive. Newborns with congenital anomalies and who were already on antibiotics prior to admission were excluded from the study. Statistical analysis was done using Statistical Package of Social Sciences (SPSS) version 17.0.

Results: 106 neonates were included in the study. MPV showed statistically significant difference between the study groups (mean 12.8±1.52, 10.82±1.20 respectively) at a cut of value of 10.2fl and a sensitivity of 93%, specificity of 84 % with a positive predictive value of 83% and negative predictive value of 94%.

Conclusions: MPV can be used as an adjuvant marker along with established septic screen to ensure early diagnosis and treatment of neonatal sepsis with no additional expense.


Keywords


IT ratio, Mean platelet volume, Micro ESR, Neonate, Preterm, Sepsis

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References


Sankar J, Agarwal R, Deorari A, Paul V. Sepsis in the newborn. Indian J Paediatr. 2008;75(3):261-6.

Million Death Study Collaborators. Causes of neonatal and child mortality in India: a nationally representative mortality survey. Lancet. 2010;376(9755):1853-60.

Panwar C, Kaushik S, Kaushik R, Sood A. Correlation of neonatal and maternal clinico-hematological parameters as predictors of early onset neonatal sepsis. Int J Contemp Pediatr. 2017;4(1):36-42.

Zea Vera A, Ochoa T. Challenges in the diagnosis and management of neonatal sepsis. J Trop Pediatr. 2015;61(1):1-13.

Shane A, Sánchez P, Stoll B. Neonatal sepsis. Lancet. 2017;390(10104):1770-80.

Muthukumaran N. Mortality profile of neonatal deaths and deaths due to neonatal sepsis in a tertiary care center in southern India: a retrospective study. Int J Contemp Pediatr. 2018;5(4):1583-7.

Ates S, Oksuz H, Dogu B, Bozkus F, Ucmak H, Yanıt F. Can mean platelet volume and mean platelet volume/platelet count ratio be used as a diagnostic marker for sepsis and systemic inflammatory response syndrome? Saudi Med J. 2015;36(10):1186-90.

Bhat R. Platelet indices in neonatal sepsis: A review. World J Clin Infect Dis. 2017;7(1):6-10.

Orak M, Karakoç Y, Üstündag M, Yildirim Y, Çelen M, Güloglu C. An investigation of the effects of the mean platelet volume, platelet distribution width, platelet/lymphocyte ratio, and platelet counts on mortality in patents with sepsis who applied to the emergency department. Niger J Clin Pract. 2018;21:667-71.

Lakhey A, Shakya H. Role of sepsis screening in early diagnosis of neonatal sepsis. J Pathol Nepal. 2017;7:1103-10.

Textbook of AIIMS protocol in Neonatology. 2019.

Catal F, Tayman C, Tonbul A, Akça H, Kara S, Tatli, et al. Mean platelet volume (MPV) may simply predict the severity of sepsis in preterm infants. Clin Lab. 2014;60(7):1193-200.

Aydın B, Dilli D, Zenciroğlu A, Karadağ N, Beken S, Okumuş N. Mean platelet volume and uric acid levels in neonatal sepsis. Indian J Pediatr. 2014;81(12):1342-6.

Yao Y, Tu Y, Lu Q. Values of C-reactive protein, percentage of neutrophils and mean platelet volume in early diagno-sis of neonatal sepsis. Zhongguo Dang Dai Er Ke Za Zhi. 2015;17:425-9.

Aksoy H, Eras Z, Guzoglu N, Canpolat F. Mean platelet volume is not associated with bacterial sepsis in newborns. Int J Infect Dis: IJID: official publication of the International Society for Infectious Diseases. 2103;17(12).