Early predictors of early onset neonatal hypocalcaemia in infants of diabetic mother

Authors

  • Bhavya S. O. Department of Paediatrics, SS Institute of Medical Sciences and Research Centre, Davanagere, Karnataka, India
  • Rachel Ranitha Department of Paediatrics, Bangalore Baptist Hospital, Bengaluru, Karnataka, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20192037

Keywords:

Apgar score, Gestational age, Hypocalcaemia, Infant of diabetic mother

Abstract

Background: The objective of this study was the magnitude of hypocalcemia and to assess the predictors for early onset neonatal hypocalcemia in infants of diabetic mother.

Methods: Total 100 infants of diabetic mother were followed for development of hypocalcaemia. weight length, gestational age, Apgar score, cord calcium was correlated for serum calcium at 48 hours of life.

Results: In present study 91% babies were term and 9% babies were preterm, the incidence of hypocalcemia was high in preterm babies i.e.22% when compared to term babies i.e. 4.3% was not significant and incidence of hypocalcemia was high in babies with Apgar <7 at 1 min (27.27%) was significant statistically. The association of hypocalcemia with cord calcium is not significant statistically.

Conclusions: The incidence of hypocalcaemia is more among preterm babies and babies with risk factors, so these babies need close monitoring for hypocalcaemia. No need of regular monitoring of calcium for healthy term babies unless they are symptomatic.

References

Fernando arias, eds. Practical guide to high risk pregnancy and delivery, 3rd e.440.

Nelson textbook of Pediatrics. 19th ed. 2016:627-629.

Cruikshank DP, Pitkin RM, Varner MW, Williams GA, Hargis GK. Calcium metabolism in diabetic mother, fetus, and newborn infant. Am J Obstetr Gynecol. 1983;145(8):1010-5.

Doi M, Rekha RS, Ahmed S, Okada M, Roy AK, Arifeen SE, et al. Association between calcium in cord blood and newborn size in Bangladesh. Br J Nutr. 2011;106(9): 1398-407.

Kovacs CS, Lanske B, Hunzelman JL, Guo J, Karaplis AC, Kronenberg HM. Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor. Proceedi Nat Acad Sci. 1996;93(26):15233-8.

Aggarwal R, Upadhyay M, Deorari AK, Paul VK. Hypocalcemia in the newborn. Ind J Pediatr. 2001;68(10):973-5.

Jain A, Agarwal R, Sankar MJ, Deorari A, Paul VK. Hypocalcemia in the newborn. Ind J Pediatr. 2010;77(10):1123-8.

Mimouni F, Tsang RC, Hertzberg VS, Miodovnik M. Polycythemia, hypomagnesemia, and hypocalcemia in infants of diabetic mothers. Am J Dis Children. 1986;140(8):798-800.

Cloherty JP, Eichenwald EC, Hansen AR, Stark AR, Manual of Neonatal Care, 7th ed.2015:297.

Cordero L, Treuer SH, Landon MB, Gabbe SG. Management of infants of diabetic mothers. Arch Pediatr Adolesc Med. 1998;152(3):249-54.

Rosenn B, Miodovnik M, Tsang R. Common clinical manifestations of maternal diabetes in newborn infants: implications for the practicing pediatrician. Pediatr Ann. 1996;25(4):215-22.

Tsang RC, Kleinman LI, Sutherland JM, Light IJ. Hypocalcemia in infants of diabetic mothers: studies in calcium, phosphorus, and magnesium metabolism and parathormone responsiveness. J Pediatr. 1972;80(3):384-95.

Mimouni F, Loughead J, Miodovnik M, Khoury J, Tsang RC. Early neonatal predictors of neonatal hypocalcaemia in infants of diabetic mothers: an epidemiologic study. Am J Perinatol. 1990;7(03):203-6.

Tsang RC, Kleinman LI, Sutherland JM, Light IJ. Hypocalcemia in infants of diabetic mothers: studies in calcium, phosphorus, and magnesium metabolism and parathormone responsiveness. J Pediatr. 1972;80(3):384-95.

Salle B, David L, Glorieux F, Delvin EE, Louis JJ, Troncy G. Hypocalcemia in infants of diabetic mothers: studies in circulating calciotropic hormone concentrations. Acta Pediatr. 1982;71(4):573-7.

Bergman L, Kjellaer I, Selatam U. Neonatal hypocalcemia in infants of diabetic mothers-hormonal effects. Pediatr Res. 1974;8(2):140.

Tsang RC, Kleinman LI, Sutherland JM, Light IJ. Hypocalcemia in infants of diabetic mothers: studies in calcium, phosphorus, and magnesium metabolism and parathormone responsiveness. J Pediatr. 1972;80(3):384-95.

Tsahg RC, Chen IW, Friedman MA, Klelnman L. Functional hypoparathyroidism in neonatal hypocalcemia of infant of diabetic mother. Pediatr Res. 1974;8(4):376.

Watney PJ, Chance GW, Scott P, Thompson JM. Maternal factors in neonatal hypocalcaemia: a study in three ethnic groups. Br Med J. 1971;2(5759):432-6.

Yaseen HA, Al-Najashi SS, Adel AA, Bahnassy AA, Al-Umran KU, Al-Faraidy AA. Predictive factors and incidence of complications in apparently healthy full-term infants of diabetic mothers. J Fam Comm Med. 1999;6(2):37.

Alam M,Raza SJ, Sherali AR, Akhtar AS, Akhtar SM. Neonatal complications in infants born to diabetic mothers. J Coll Physicians Surg Pak. 2006;16(3):212-5.

Downloads

Published

2019-04-30

Issue

Section

Original Research Articles