DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20193161

A study of biochemical abnormalities and manifestations of neonatal seizures

Sahaya Nirmala, Sahana Giliyaru, S. C. Karat

Abstract


Background: Neonatal seizure is a common neurological problem in the neonatal period with a frequency of 1.5 to 14/1000 neonates1. Neonatal seizures have always been a topic of particular interest because of their universal occurrence. A varied number of conditions are capable of causing seizures in the neonatal period. The presence of a seizure does not constitute a diagnosis but is a symptom of an underlying central nervous system disorder due to systemic or biochemical disturbances. This study aims to study the various clinical types of seizures and the biochemical abnormalities associated with them.

Methods: This prospective study was conducted in the neonatology unit, department of pediatrics, C.S.I. Holdsworth Memorial Hospital, Mysore. Details of history, examination and investigations were recorded on predesigned proforma.

Results: Out of total 54 cases, 47(87%) cases had seizures during first 3 days of life and hypoxic ischemic – encephalopathy (HIE) remains the main etiological factor in 20 (37.04%) cases. More than one metabolic abnormality was present in 6 cases. Hypoglycemia & hypomagnesemia were the commonest abnormality in neonates having seizures.

Conclusions: A biochemical work up is necessary for all cases of neonatal seizures. The type of seizure does not give much information as to whether the seizures are purely metabolic or organic or about the type of biochemical abnormality.


Keywords


Biochemical abnormalities, Etiology, Hypoglycemia, Hypomagnesemia, Mysore, Neonatal Seizures

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References


Airede KI. Neonatal seizures and a 2-year neurological outcome. J Trop Pediatr. 1991;37(6):313-7.

Lanska MJ, Lanska DJ, Baumann RJ, Kryscio RJ. A population-based study of neonatal seizures in Fayette county, Kentucky. Neurology. 1995;45(4):724-32.

Scher MS. Neonatal seizures and brain damage. Pediatr Neurol. 2003;29:381-90.

Volpe JJ. Neonatal seizures. In: Volpe JJ, eds. Neurology of the Newborn. 4th Ed. Philadelphia: saunders; 2001:178-214.

Zupana ML. Neonatal seizures. Pediatr Clin N Am. 2004;51(4):961-78.

Laroia N. Curret controversies in diagnosis and management of neonatal seizures. 2000;37(4):367-72.

Rose AL, Lombroso CT. A study of clinical, pathological and electroencephalographic features in 137 full term babies with a long term follow up. Pediatrics. 1969;45(3):404-25.

Volpe J. Neonatal seizures. N Engl J Med. 1973;289(8):413-6.

Keen JH. Significance of hypocalcemi in neonatal convulsions. Arch. Dis Childh. 1969;44(235):342-5.

Brown JK, Cockburn, Forfar JO. Clinical and chemical correlates in convulsions of the newborn. Lancet. 1972;299(7742):135-9.

Brown JK. Convulsions in newborn period. Develop Med Child Neurol. 1973;15(6):823-46.

Goldberg HJ, Sheely EM. Fifth day fits an acute zinc deficiency syndrome. Arch Dis child. 1982;57(8):633-6.

Eriksson M, Zetterstrom R. Neonatal convulsions: Incidence and causes in the Stockholm area. Acta Paediatrca. 1979;68(6):807-11.

Bergman I, Painter MJ, Hirsch RP, Crumrine PK, David R. Outcome in neonates with convulsions treated in an intensive care unit. 1983;14(6):642-7.

Goldberg HJ. Neonatal convulsions- a 10-year review. Arch Dis Child. 1983;58(12):976-8.

Garg PK. Neonatal seizures. Ind J. Pediatr. 1972; 39(293):208-13.

Calciolari G, Perlman JM, Volpe JJ. Seizures in the neonatal intensive care unit of the 1980s. Clinical Pediatr. 1988;27(3):119-23.

Kumar A, Gupta V, Kachnakunn JS, Single PN. Biochemical abnormalities in neonatal seizures. Indian Pediatr. 1995;32(4):424-8.

Sood A, Grover N, Sharma R. Biochemical abnormalities in neonatal seizures. Indian J Pediatr. 2003;70(3):221-4.