Status of trace elements zinc, copper, and selenium in transfusion dependent beta thalassemic Indian children: a cross sectional study

Authors

  • Babulal Choudhary Department of Pediatrics, Dr. SN Medical College, Jodhpur, Rajasthan, India http://orcid.org/0000-0001-6614-8436
  • Anurag Singh Department of Pediatrics, Dr. SN Medical College, Jodhpur, Rajasthan, India
  • Vishnu K. Goyal Department of Pediatrics, Dr. SN Medical College, Jodhpur, Rajasthan, India
  • Pramod Sharma Department of Pediatrics, Dr. SN Medical College, Jodhpur, Rajasthan, India
  • G. S. Totetja Centre for Promotion of Nutrition Research and Training with Special Focus on North-East, Tribal and Inaccessible Population (Indian Council of Medical Research), New Delhi, India
  • Vikas Payal Department of Pediatrics, Dr. SN Medical College, Jodhpur, Rajasthan, India
  • Zaozianlungliu Gonmei Centre for Promotion of Nutrition Research and Training with Special Focus on North-East, Tribal and Inaccessible Population (Indian Council of Medical Research), New Delhi, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20193746

Keywords:

Copper, Selenium, Thalassemia, Trace elements, Zinc

Abstract

Background: Maintenance of normal levels of copper, selenium, and zinc play an important part in lessening the morbidities associated with thalassemia major. Levels of these elements have been found to be altered in this chronic transfusion dependent disease from all over the world, but with widely variable results.  Besides repeated blood transfusions and use of chelating agents, their levels in thalassemics are affected by genetic and dietary factors also, compelling us to undertake this study in our population. The objectives of this study were assessment of serum levels of zinc, copper and selenium in transfusion dependent beta thalassemics.  

Methods: Cross sectional descriptive study conducted at Thalassemia Day-care Centre of a teaching hospital. Total 64 transfusion dependent thalassemics in the age group 3-18 years were subjected to serum levels of zinc, copper and selenium by inductively coupled plasma mass spectrometry technique.   

Results: Four (6.25%) had hypozincemia, 15 (23.43%) hypocupremia and one (1.565%) had hypercupremia. Two (3.12%) had higher selenium levels (>190 µgm/l).

Conclusions: In contrast to previous studies, hypocupremia has been found to be more prevalent than hypozincemia and hyposelenemia in our population.

References

Thacker N. Prevention of thalassemia in India. Indian Pediatrics 2007;44(9):647-8.

Malakar R, Kour M, Ahmed A, Malviya S.N, Dangi C.B.S. Trace Elements Ratio in Patients of Haemoglobinopathie: Review Article. Int J Curr Microbiol App Sci. 2014;3(6):81-92.

Mashhadi MA, Sepehri Z, Heidari Z, Shirzaee E, Kiani Z. The Prevalence of Zinc Defiiency in Patients with Thalassemia in South East of Iran, Sistan and Baluchistan Province. Iran Red Crescent Med J. 2014;16(8):1-4.

Mahyar A, Ayazi1P, Pahlevan AA, Mojabi H, Sehhat MR, Javadi A. Zinc and Copper Status in Children with Beta Thalassemia Major. Iran J Pediatr. 2010;20(3):297-302.

Mansi K, Aburjai T, Barqawi M, Naser H. Copper and zinc status in Jordian patients with beta-thalassemia major treated with deferoxamine. Res J Biol Sci. 2009;4(5):566-72.

McCall KA, Huang C, Fierke CA. Function and mechanism of zinc metalloenzymes. J Nutr 2000;130:1437S-6.

MacDonald RS. The role of zinc in growth and cell proliferation. J Nutr. 2000;130:1500S-8.

Fung EB. Nutritional deficiencies in patients with thalasemia. Ann NY Acad Sci. 2010;1202:188-96.

Angelova M, Asenova S, Nedkova V, Koleva-Kolarova R. Copper in the human organism: a mini review. Trakia J Sci. 2011;9(1):88-98.

Sherief LM, Abd El-Salam SM, Kamal NM, El safy O, Almalky MAA, Azab SF et al. Nutritional biomarkers in children and adolescents with beta-thalassemia-major: An Egyptian center experience. Bio Med Res Inter. 2014;2014.

Mashhadi MA. Copper status in patients with thalassemia major in Zahedan, Iran. Int J Hematol Oncol Stem Cell Res. 2013;7(3):21-4.

Bartlay WJ, Bartfay E. Selenium and glutathione peroxidase with beta-thalassemia major. Nurs Res. 2001;50(3):178-83.

Atasever B, Ertan NZ, Erdem-Kuruca S, Karakas Z. In vitro effects of vitamin C and selenium on NK activity of patients with β-thalassemia major. Pediatr Hematol Onco. 2006;23(3):187-97.

Missiry ME, Hussein MH, Khalid S, Yaqub N, Khan S, Itrat F, et al. Assessment of Serum Zinc Levels of Patients with Thalassemia Compared to Their Siblings. Anemia. 2014;2014.

Fikry SI, Saleh SA, Sarkis NN, Mangoud H. Study of serum zinc in relation to nutritional status among thalassemia patients in Damanhour Medical National Institute. J Egypt Public Health Assoc. 2003;78(1-2):73-93.

Al-Samarrai AH, Adaay MH, Al-Tikriti KA, Al-Anzy MM. Evaluation of some essential element levels in thalassemia major patients in Mosul district, Iraq. Saudi Med J. 2008;29(1):94-7.

Cianciulli P, Sollecito D, Sorrentino F, Forte L, Gilardi E, Massa A, et al. Early detection of nephrotoxic effects in thalassemic patients receiving desferrioxamine therapy. Kidney Int. 1994;46(2):467-70.

Uysal Z, Akar N, Kemahli S, Dincer N, Arcasoy A. Desferrioxamine and urinary zinc excretion in beta-thalassemia major. Pediatr. Hematol Oncol. 1993;10(3):257-60.

Tabatabei M, Kamkar M, Habibzadeh MR. Metabolic and endocrine complications in beta‐thalassemia major; a multicenter study in Tehran. Boshehr Med J. 2003;5(1):72‐3.

Galanello R. Deferiprone in the treatment of transfusiondependent thalassemia: a review and perspective. Thera Clin Risk Manag. 2007;3(5):795-805.

Cappellini MD. Exjade (deferasirox, ICL670) in the treatment of chronic iron overload associated with blood transfusion. Ther Clin Risk Manag. 2007;3(2):291-9.

Mehdizadeh M, Zamani G, Tabatabaee S. Zinc status in patients with major beta thalassemia. Pediatr Hematol Oncol. 2008;25(1):49-54.

Kajanachumpol S, Tatu T, Sasanakul W, Chuansumrit A, Hathirat P. Zinc and copper status of thalassemia children. Southeast Asian J Trop Med Public Health. 1997;28(4):877‐80.

Fuchs GJ, Tienboon P, Linpisarn S, Nimsakul S, Leelapat P, Tovanabutra S, et al. Nutritional factors and thalassaemia major. Arch Dis Child. 1996;74(3):224‐7.

Bashir NA. Serum zinc and copper levels in sickle cell anemia and beta‐thalassemia in north Jordan. Ann Trop Paediatr. 1995;15(4):291‐3.

Mashhadi M, Heidari Z, Sepheri Z, Bakhshipour AR, Karimkoshte A. The selenium status in thalassemia patients in South East of Iran. Int J Hematol Oncol Stem Cell Res. 2014;8(4):1-4.

Downloads

Published

2019-08-23

Issue

Section

Original Research Articles