DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20194732

Syndrome of inappropriate antidiuretic hormone secretion in neonates with birth asphyxia at tertiary care centre

Vijayalaxmi Gagandeep, Vidhya P. S.

Abstract


Background: Syndrome of inappropriate antidiuretic hormone is an important metabolic complication of perinatal asphyxia. This study aims to study the occurrence of syndrome of inappropriate antidiuretic hormone in different grades of perinatal asphyxia and to find out the correlation of syndrome of inappropriate antidiuretic hormone to gestational age and birth weight in birth asphyxiated babies.

Methods: It was a hospital-based cohort study. 50 neonates with different grades of asphyxia were enrolled in the study and 50 controls were taken. Syndrome of inappropriate antidiuretic hormone was diagnosed based on calculated plasma osmolality, serum and urine sodium, urine specific gravity and analyzed with different grades of birth asphyxia and birthweight and gestation age.

Results: The occurrence of SIADH in birth asphyxiated babies was 26% and none of the babies in control group developed SIADH. The occurrence was more in the severely asphyxiated babies (53.8%), followed by moderate (30.8%) and then mildly asphyxiated babies (15.4%). Hyponatremia was seen in 26% of birth asphyxiated babies and can be used as a marker of SIADH. In relation to gestation age and birth weight there was no statistically significant correlation between SIADH and different grades of asphyxia. Mortality was high among the neonates who developed SIADH.

Conclusions: The occurrence of SIADH was 26% in asphyxiated neonates and high in severe asphyxia and gestation age and birth weight beard no significant co relation.


Keywords


Birth asphyxia, Birth weight, Gestation age, Hyponatremia, Neonates, SIADH (Syndrome of Inappropriate Antidiuretic Hormone)

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References


NNPD Network. National Neonatal Perinatal Database- report for the year 2002-2003. NNF NNPD Network. New Delhi. 2005;13-19.

Apgar V. A proposal for a new method of evaluation of the newborn infant. Curr Res Anesth Analg. 1953;32:260-7.

Levene M, Evans D. Hypoxic ischaemic encephalopathy. Roberton Textbook of neonatology. Rennie J M eds. 4th ed. Elsevier, Churchil Living Stone Publishers. 2005: 1128-1144.

Volpe JJ. Hypoxic-ischemic encephalopathy: neuropathology and pathogenesis. In: Volpe JJ. Neurology of the newborn, 3rd ed. WB Saunders: Philadelphia; 1995: 279-313.

Kecskes Z, Healy G, Jensen A. Fluid restriction for term infants with hypoxicā€ischaemic encephalopathy following perinatal asphyxia. Cochrane Database of Systematic Reviews. 2005(3).

Gupta HV, Dalal JS, Sethi GK, kumar A, Bajaj H, Locham KK. Syndrome of inappropriate ADH secretion (SIADH) in birth asphyxia and its comparison in different grades of Birthasphyxia, gestation and Birthweight. J Neonat. 2013;27(1):25-28.

Phelan J, Korst LM, Martin GI. Syndrome of inappropriate antidiuretic hormone (SIADH) among asphyxiated neonates with permanent brain injury: A potential marker to time fetal brain injury. Am J Obstetri Gynecol. 2006;195(6):S180.

Rees L, Brook CGD, Shaw JCL, Forsling M L. Hyponatremia in the first week of life in preterm infants. Arch Dis Chil. 1984;59:414-22.

Speer ME, Gorman WA, Kaplan SL, Rudolph AJ. Elevation of plasma concentration of Arginine Vasopressin following perinatal asphyxia. Acta Pediatr Scand. 1984;73:610-14.

Mamun MA, Hossain MM, Shirin M, Qader A, Hasan NA, Hoque A. Incidence and outcome of SIADH in neonate DS. Child J. 2015;28(1):35-40.