DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20195758

Case report of a male child with lupus nephritis

Richa ., Shashi Sharma, Pankaj Abrol

Abstract


Systemic lupus erythematosus is a chronic autoimmune inflammatory disease of unknown etiology that affects various organs, most frequently the skin, joints, kidneys, nervous, hematologic and cardiovascular systems. It affects females more often as compared to males. The kidneys are one of the most serious organs involved. Lupus nephritis may present as hypertension, proteinuria, and renal failure or it may also be asymptomatic. The recent reports suggest that childhood-onset lupus nephritis could be more severe than the late-onset disease. The occurrence of SLE in pediatric patients is very rare, especially in a male child. Here author report a case of an 8-year-old male child clinically misdiagnosed as a case of henoch schonlein purpura, who was thoroughly investigated and finally confirmed as a case of lupus nephritis.


Keywords


Antibody, Autoimmune, Biopsy, Lupus nephritis, Male, Systemic lupus erythematosus

Full Text:

PDF

References


Perfumo F, Martini A. Lupus nephritis in children. Lupus. 2005;14:83-8.

Hiraki LT, Benseler SM, Tyrrell PN, Hebert D, Harvey E, Silverman ED. Clinical and laboratory characteristics and long-term outcome of pediatric systemic lupus erythematosus: a longitudinal study. J Pediatr. 2008;152:550-6.

Ruperto N, Ravelli A, Cuttica R, Espada G, Ozen S, Porras O, et al. The Pediatric Rheumatology International Trials Organization criteria for the evaluation of response to therapy in juvenile systemic lupus erythematosus: prospective validation of the disease activity core set. Arthr Rheum. 2005 Sep;52(9):2854-64.

Hiraki LT, Silverman ED. Genomics of systemic lupus erythematosus: insights gained by studying monogenic young-onset systemic lupus erythematosus. Rheum Dis Clin. 2017 Aug 1;43(3):415-34.

Costa-Reis P, Sullivan KE. Monogenic lupus: it's all new!. Curr Opin Immunol. 2017 Dec 1;49:87-95.

Tao JJ, Hiraki LT, Levy DM, Silverman ED. Comparison of Sensitivities of American College of Rheumatology and Systemic Lupus International Collaborating Clinics Classification Criteria in Childhood-onset Systemic Lupus Erythematosus. J Rheumatol. 2019 Feb 15:180337.

Cynthia G, Avner ED. In: Kliegmann, Stanton, St Geme, Schor, eds. Nelson Textbook of Paediatrics. 20th ed. South Asia, Elsevier; 2015: 2503-2505.