DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20201147

Comparison of EEG changes in neonatal period and three months of age in patients with history of neonatal seizure

Farzad Ahmadabadi, Mehrdad Mirzarahimi, Masoumeh Babaei, Sanaz Karimi Dardashti

Abstract


Background: The prevalence of neonatal seizure in term neonates is 3 per 1000 births, but in preterm newborns is 50 per 1000 births. Babies who have seizures are at high risk of death or neurological disabilities. Seizure is often the first sign of neonatal dysfunction and may be effective in long-term prognosis. EEG is the only available method for the diagnosis of seizures in neonates. Therefore, authors compared EEG changes in the first EEG infant seizure with 3 months of age in newborns who referred to the Aristotelian hospital in Bouali Hospital.

Methods: The present study is a cross-sectional descriptive analytical method. In this study, neonates referred to Ardabil Booali Hospital, EEG, were screened for seizure and EEG was monitored 3 months later and the results were evaluated. Finally, all the data were entered into the SPSS-24 statistical analysis program and authors analyzed the data according to the type of variables by statistical tests.

Results: In this study, 50 neonates with seizure were enrolled in this study, 70% of which had an average age of 14.92 days. 80% of infants were born at the time of term. The average birth weight was 3.208 kg. 6.2% of infants had abnormal CT scan findings, with an IVH infant and one baby showing brain edema. In this study, only 14% of neonates with abnormal brain strain were observed in the neonatal period and near the seizure. However, after 3 months, 40% of infants experienced abnormal brain stroke findings. Among the changes in EEG with age (p=0.173), gestational age (p=0.616), gender (p=0.176), seizure (p=0.145), neonatal hypoglycemia (p=0.594), hypocalcaemia (p=0.607) no statistic was found.

Conclusions: The  results of  this study  showed  that a  small  percentage of  neonates had abnormal EEG in the neonate, but after 3 months of seizure, the larger percentage of them found abnormal EEG.


Keywords


Electroencephalography, Neonatal, Seizure

Full Text:

PDF

References


Greene BR, Faul S, Marnane WP, Lightbody G, Korotchikova I, Boylan GB. A comparison of quantitative EEG features for neonatal seizure detection. Clin Neurophysiol. 2008 Jun;119(6):1248-61.

Scher MS, Aso K, Beggarly ME, Hamid MY, Steppe DA, Painter MJ. Electrographic seizures in preterm and full-term neonates: clinical correlates, associated brain lesions, and risk for neurologic squeal. Pediatrics 1993;91(1):128-34

Hellstrome-westas L, Blennow G, Lindroth M, Rosen I, Svenningsen NW. Low risk of seizure recurrence after early withdrawal of antiepileptic treatment in the neonatal period. Arch Dis Child 1995;72:97-101.

Lanska MJ, Lanska DJ, Baumann RJ, Krysio RJ. A population-based study of neonatal seizures in Fayette country. Neurology 1995;45:724-32 .

Shellhaas RA, Soaita AI, Clancy RR. Sensitivity of amplitude-integrated electroencephalography for neonatal seizure detection. Pediatrics 2007; 120(4):770-7.

Brunquell PJ, Glennon CM, Dimario FJ, Lever T, Eisefeld L. Prediction of outcome based on clinical seizure type in newborn infants. J pediatr 2004;140: 707-12.

Shellhaas RA, Clancy RR. Characterization of neonatal seizures by conventional EEG and single-channel EEG. Clin Neurophysiol. 2007 Oct;118(10):2156-61.

Temko A, Thomas E, Marnane W, Lightbody G, Boylan G. EEG-based neonatal seizure detection with Support Vector Machines. Clin Neurophysiol. 2011 Mar;122(3):464-73.

Co JP, Elia M, Engel J Jr, Guerrini R, Mizrahi EM, Moshé SL, et al. Proposal of an algorithm for diagnosis and treatment of neonatal seizure in developing countries. Epilepsia 2007;48(6):1158- 64.

Sanker R, Koh S, Wu J, Menkes JH. Paroxysmal disorders in: Menkes child neurology. Philadelphia Williams & Wilkins company. 2005:922-6.

Fallah R, Abedi M. The evaluation of children brain CT scan results and it's relationship with requesting clinical complaints. Horizon Med Sci. 2008;14(1):27-32

Dehdyshtan M, Momen A, Kajbaf ZT, Mordakhani SH. Investigating the causes of seizure in admitted infants due to seizure in Imam Khomeini (AH) and Ahvaz Aboozar hospitals from 2003 to 2005. Jundishapur Scientific Med J. 2008;8(2):163-7.

Abbaskhanian A, Mohammadi M, Farhadi R, Khademloo M. Prevalence and associated factors of neonatal seizure in neonates admitted in neonatal ward of Bu-Ali Sina and Imam Khomeini hospitals, Sari, Iran. J Mazandaran Univ Med Sci. 2014;23(2):89-94.

Najeeb S, Qureshi AM, Anis-ur-Rehman, Ahmad F, Shah S, Khan AY, et al. Aetiology and types of neonatal seizures presenting at Ayub Teaching Hospital Abbottabad. J Ayub Med Coll Abbottabad. 2012 Jan-Mar;24(1):33-7.

Yıldız EP, Tatlı B, Ekici B, Eraslan E, Aydınlı N, Calışkan M, et al. Evaluation of etiologic and prognostic factors in neonatal convulsions. Pediatr Neurol. 2012 Sep;47(3):186-92.

Shahraki Nasab F "Determination of frequency of seizure which can be detected in hospitalized patients in neonatal department" Ph.D. thesis, Zahedan University of Medical Sciences, 2000.

Koelfen W, Freund M, Varnholt V. Neonatal stroke involving the Middle cerebral artery in term infants: clinical presentation, EEG and imaging studies, and outcome. Devel Med Child Neurol. 1995;37:204-12.

Clancy R, Malin S, Laraque D, Baymgart S, Younkin D. Focal motor seizuresheralding stroke in full term neonates. Am J Dis Child. 1985;139:601-6.

Ashrafzadeh F, Mahmoodi E, Hydarian F, Kharazmi A. Outcome of term neonates with identified seizures. Horizon Med Sci . 2006;11(4):37-41.

Almubarak S, Wong PK. Long-term clinical outcome of neonatal EEG findings. J Clin Neurophysiol. 2011 Apr;28(2):185-9.

Anand V, Nair PMC. Neonatal seizures: Predictors of adverse outcome. J Pediatr Neuroscie. 2014;9(2):97-9.

Pisani F, Spagnoli C. Neonatal Seizures: A Review of Outcomes and Outcome Predictors. Neuropediatr. 2016 Jan;47(1):12-9.

Shahibi NS, Fakhraee H, Afjeei A, Kazemian M. Ischemic brain lesions and brain imaging findings in neonates with seizure. 2009;13(4):347-53.