Study the iron status in children with febrile seizures: a hospital based cross sectional study

Authors

  • Rajat Goyal Department of Pediatrics, Himalayan Institute of Medical Sciences, Jollygrant, Dehradun, Uttarakhand, India
  • Alpa Gupta Department of Pediatrics, Himalayan Institute of Medical Sciences, Jollygrant, Dehradun, Uttarakhand, India
  • Neerul Pandita Department of Pediatrics, Himalayan Institute of Medical Sciences, Jollygrant, Dehradun, Uttarakhand, India
  • Anita Sharma Department of Biochemistry, Himalayan Institute of Medical Sciences, Jollygrant, Dehradun, Uttarakhand, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20203640

Keywords:

Febrile seizures, Iron status, Neurotransmitters, Serum ferritin, Serum iron

Abstract

Background: Febrile seizures are most common among childhood seizures, accounts to 2% to 5% in children below 5 years of age. Iron deficiency can cause many neurological deficits and may lower the seizure threshold. The present study was conducted to determine the iron status in children with febrile seizures.

Methods: The present cross-sectional study was conducted in the Department of Pediatrics, HIMS, Dehradun, over a period of 12 month from January 2018 to December 2018. A total of 105 children of age group 6 month to 5 years, coming to pediatrics department were included in the study. Total study subjects were divided into two groups, Group I (febrile seizure) and Group II (other than febrile seizure).  A consecutive sampling method was done for selection of study subjects.

Results: In Group I (febrile seizure), the number of males were 71.7% while females were 28.3% with male: female ratio of 2.5:1. In Group I (febrile seizure), 61.7% of subjects had deficient iron level while 38.3% of subjects had normal serum iron level. Our study shows significantly low mean serum ferritin and mean serum iron level in subjects with febrile seizures.

Conclusions: We concluded that iron deficiency is more common in febrile seizures and there is a positive association between serum iron level and febrile seizures.

Author Biographies

Rajat Goyal, Department of Pediatrics, Himalayan Institute of Medical Sciences, Jollygrant, Dehradun, Uttarakhand, India

Junior Resident, Department of Pediatrics, Himalayan institute of Medical sciences , SRHU

Alpa Gupta, Department of Pediatrics, Himalayan Institute of Medical Sciences, Jollygrant, Dehradun, Uttarakhand, India

Professor and Head, Department of Pediatrics, Himalayan institute of Medical sciences , SRHU

Neerul Pandita, Department of Pediatrics, Himalayan Institute of Medical Sciences, Jollygrant, Dehradun, Uttarakhand, India

Associate Professor, Department of Pediatrics, Himalayan institute of Medical sciences , SRHU

Anita Sharma, Department of Biochemistry, Himalayan Institute of Medical Sciences, Jollygrant, Dehradun, Uttarakhand, India

Professor, Department of Biochemistry, Himalayan institute of Medical sciences , SRHU

References

Singh P, Mehta V. Is iron deficiency anaemia a risk factor for febrile seizure: A case control study. Int J Contemp Pediatr. 2016;3(4):1307-11.

Moruskar AD, Kumbhar S G, Kulkarni M, Sale M. Prospective study of iron deficiency status in febrile seizures. International J Health Care Biomed Res. 2016;04(03):40-8.

Gupta S, Agarwal N, Maheshwari M. Iron Deficiency as a risk factor for febrile seizures – a case control study. PJSR. 2015;8(2):37-40.

Nasehi MN, Abbaskhanian A, Omran MRS. Association between iron deficiency anemia and febrile seizure: a systematic review and meta-analysis. J Pediatr Rev. 2013;1(2):13-8.

Chandrasekhar RV, Sasibhushan G, Vijaya Lakshmi B. Iron deficiency as a risk factor for febrile seizures. Inter J Pediatric Res. 2016;3(4):269-73.

International Institute for Population Sciences (IIPS), 2007. National Family Health Survey (NFHS-3), Indian volume I. Mumbai: IIPS; 2005-06.

Kimber RJ, Rusaki Z, Blunden RW. Iron deficiency and iron overload: serum ferritin and serum iron in clinical medicine pathology. 1983;15:497-503.

Shah H, Shah B, Banker D, Pandya D, Shah V, Shah A. Study of association of Iron deficiency anaemia and simple febrile seizures in 6-60 months children: a case control study. Int J Pediatr Res.016;3(2):86-9.

Gowda ANBL, Samuel PC. Study on association of iron status in children with simple febrile seizure and without seizures. Int J Contemp Pediatr. 2018;5(4):1300-3.

Stanley FL. Reference intervals for laboratory tests and procedures: Staton BF, Schor NF, Geme JW, editors. Nelson Textbook of Pediatrics. 20th Edition. Thomas Press India Ltd: Elsevier; 2015: 3465.

Kumawat R, Garg P, Karnawat BS, Verma IP, Arora A, Sonkaria M. Study of iron deficiency as a risk factor for first episode of simple febrile seizure. Int J Contemp Pediatr. 2017;4(5):1881-5.

Nigadge RM, Khambalkar DV. Iron deficiency anaemia and its association with febrile seizures. Int J Contemp Pediatr. 2018;5(3):1120-25.

Ghasemi F, Valizadeh F, Taee N. Iron-deficiency Anemia in Children with Febrile Seizure: A Case-Control Study. Iran J Child Neurol. 2014;8(2):38-44.

Fallah R, Tirandazi B, Akhavan KS, Golestan M. Iron deficiency and iron deficiency anemia in children with febrile seizure. Iranian J Pediatric Hematol Oncol. 2013;3(1):19-23.

Akbar MA, Roya N, Babak K. Evaluation of iron status in 9-month to 5-year-old children with febrile seizures: a case-control study in the south west of Iran. Iran J Child Neurol. 2010;4(2):45-50.

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Published

2020-08-25

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Original Research Articles