DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20202079

Correlation of serum level and selective blood indices in children with feberile seizures in Chittoor district, India

Rajesh Kumar V., Ande Penchalaiah

Abstract


Background: A seizure or convulsion is a paroxysmal, time-limited change in motor activity and/or behavior that result from abnormal electrical activity in the brain. Seizures are common in the pediatric age group and occur in approximately 10% of children. Most seizures in children are provoked by somatic disorders originating outside the brain, such as high fever, infection, syncope, head-trauma, hypoxia, toxins, or cardiac arrhythmias. To study the association between iron deficiency and the first febrile seizure.

Methods: The present study is a retrospective study conducted at the teaching hospital, Chittoor district from August 2019 to December 2019. In this study to detect low iron status as a possible risk factor for first febrile seizures, 63 cases, and 63 age and sex-matched controls are studied and analyzed.

Results: In this study family history of febrile seizures is seen only in 28.5% of cases. The mean serum ferritin level in this study is 14.5ng/ml. Thus the mean serum ferritin, HB, and MCV are found to be signed on the lower side among children with febrile seizures.

Conclusions: Plasma ferritin level and blood indices are significantly lower in children with febrile seizures as compared to children without febrile seizures suggesting that iron-deficient children are more prone to febrile seizures.


Keywords


Febrile seizures, Iron deficiency anemia, Mean Corpascular Volume, Serum ferritin

Full Text:

PDF

References


Livingston S. Comprehensive management of epilepsy in infancy, childhood and adolescence. Springfield, IL: Charles Thomas. 1972:268-74.

National Institutes of Health. Consensus development conference on febrile seizures. Epilepsia. 1981;22:377-81.

Frantzen E, Lennox-Buchthal M, Nygaard A, Stene J. A genetic study of febrile convulsions. Neurology. 1970 Sep 1;20(9):909-.

Rantala H, Uhari M. Risk factors for recurrences of febrile convulsions. Acta Neurol Scandinav. 1994 Sep;90(3):207-10.

Sahib El-Radhi A, Withana K, Banajeh S. Recurrence rate of febrile convulsion related to the degree of pyrexia during the first attack. Clini Pediatr. 1986 Jun;25(6):311-3.

Doose H, Ritter K, Völzke E. EEG Longitudinal Studies in Febrile Convulsions1. Neuropediatrics. 1983 May;14(02):81-7.

Nelson KB, Ellenberg JH. Predictors of epilepsy in children who have experienced febrile seizures. New Engl J Medi. 1976 Nov 4;295(19):1029-33.

Annegers JF, Hauser WA, Shirts SB, Kurland LT. Factors prognostic of unprovoked seizures after febrile convulsions. New Engl J Medi. 1987 Feb 26;316(9):493-8.

Camfield P, Camfield C, Cordon K, Dooley J. What types of epilepsy are preceded by febrile seizures? A popilation‐based study of children. Developm Medi Child Neurol. 1994 Oct;36(10):887-92.

Chevrie JJ, Aicardi J. Duration and lateralization of febrile convulsions. Etiological factors. Epilepsia. 1975 Dec;16(5):781-9.

Gastaut H, Poirier F, Payan H, Salamon G, Toga M, Vigouroux MH. HHE syndrome hemiconvulsions, hemiplegia, epilepsy. Epilepsia. 1959 Jan;1(1‐5):418-47.

Berg AT, Shinnar S, Darefsky AS, Holford TR, Shapiro ED, Salomon ME, et al. Predictors of recurrent febrile seizures: a prospective cohort study. Arch Pediatr Adolesc Medi. 1997 Apr 1;151(4):371-8.

Ellenberg JH, Nelson KB. Febrile seizures and later intellectual performance. Arch Neurol. 1978 Jan 1;35(1):17-21.

Daoud AS, Batieha A, Al-Sheyyab M, Abuekteish F, Hijazi SA. Effectiveness of iron therapy on breath-holding spells. J Pediatr. 1997 Apr 1;130(4):547-50.

Billoo AG. Association between iron deficiency anemia and febrile seizures. J Coll Physic Surg-Pak. 2005 Jun;15(6):338-40.

Pisacane A, Sansone R, Impagliazzo N, Coppola A, Rolando P, D'Apuzzo A, et al. Iron deficiency anaemia and febrile convulsions: case-control study in children under 2 years. Br Medi J. 1996 Aug 10;313(7053):343-4.

Kobrinsky NL, Yager JY, Cheang MS, Yatscoff RW, Tenenbein M. Does iron deficiency raise the seizure threshold?. J Child Neurol. 1995 Mar;10(2):105-9.