Transmission of SARS-CoV-2 infection mother to the newborn

Bonifacio Caballero, Daniel Caballero


The emergence of the new corona virus infection that occurred in Wuhan, the capital city of China's Hubei province in December 2019 initially labeled 2019-nCoV and later named SARS-CoV-2, has spread in several countries around the world and subsequently raised concerns about the possibility of vertical transmission from the mother to the fetus, producing its disease named COVID-19. Around 12 articles about pregnant women infected with COVID-19 and their newborns have been published between February 10 and April 4, 2020. So far, there are few reports on newborns. There is currently evidence of vertical transmission from pregnant women with COVID-19 infection during the third trimester. The results of this report suggest that currently there is evidence of intrauterine infection caused by vertical transmission in women who develop COVID-19 pneumonia and die in late pregnancy. However, most of these newborns have been asymptomatic or mildly symptomatic, but as the outbreak and information are changing rapidly, it is recommended to continue to check for updates.


COVID-19, Newborns, Pregnancy, Vertical transmission, SARS-CoV-2

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World Health Organization. Naming the coronavirus disease (COVID-2019) and the virus that causes it. Available at:

diseases/novelcoronavirus2019/technicalguidance/naming-the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it Accessed 03 May 2020.

World Health Organization. Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected. Interim guidance. Available at: Accessed 12 January 2020.

Alfaraj H, Tawfiq A, Memish A. Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection during pregnancy: Report of two cases & review of the literature. J Microbiol Immunol Infect. 2019;52:501-3.

Jeong Y, Sung I, Sung H, Ahn Y, Kang S, Chang S, et al. MERS-CoV infection in a Pregnant Woman in Korea. J Korean Med Sci. 2017;32:1717–20.

Alserehi H, Wali G, Alshukairi A, Alraddadi B. Impact of Middle East Respiratory Syndrome coronavirus (MERS-CoV) on pregnancy and perinatal outcome. BMC Infect Dis 2016;16:105.

Assiri A, Abedi R, Al Masri M, Saeed B, Gerber S, Watson T. Middle East Respiratory Syndrome Coronavirus Infection During Pregnancy: a Report of 5 Cases From Saudi Arabia. Clin Infect Dis. 2016;63:951-3.

Malik A, Masry M, Ravi M, Sayed F. Middle East Respiratory Syndrome Coronavirus during Pregnancy, Abu Dhabi, United Arab Emirates, 2013. Emerg Infect Dis. 2016; 22:515-7.

Park H, Kim R, Choi H, Sung H, Kim H. Emergency cesarean section in an epidemic of the Middle East respiratory syndrome: a case report. Korean J Anesthesiol. 2016;69:287-91.

Payne C, Iblan I, Alqasrawi S, Nsour A, Rha B, Tohme A, et al. Stillbirth during infection with Middle East respiratory syndrome coronavirus. J Infect Dis. 2014;209:1870-2.

Yudin H, Steele M, Sgro D, Lea E, Kopplin P, Gough A. Severe acute respiratory syndrome in pregnancy. Obstet Gynecol. 2005;105:124-7.

Wong F, Chow M, Leung N, Ng F, Ng K , Sheket C, et al. Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Am J Obstet Gynecol. 2004;191:292-7.

Lam M, Wong F, Leung N, Chow M, Yu C, Wonget Y, et al. A case‐controlled study comparing clinical course and outcomes of pregnant and non‐pregnant women with severe acute respiratory syndrome. Int J Obstre. Gynaeco. 2004;111:771-4.

Robertson A, Lowther A, Birch T, Tan h, Sorhage F, Stockman L, et al. SARS and pregnancy: a case report. Emerg Infect Dis. 2004;10:345-8.

Schneider E, Duncan D, Reiken M, Perry R, Messick J, Sheedy C, et al. SARS in pregnancy: this case study explores the first documented infection in the U.S.A. WHONN Lifelines 2004;8:122-8.

Stockman J, Lowther A, Coy K, Saw J, Parashar D. SARS during pregnancy, United States. Emerg Infect Dis. 2004;10:1689-90.

World Health Organization. Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases. Interim guidance, 2020. Available at: Accessed on 4 May 2020.

Corman M, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu K,et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill 2020;25:2000045.

Liu D, Li L, Xin W, Zheng D, Wang J, Yanget L, et al. Pregnancy and Perinatal Outcomes of Women with COVID-19 Pneumonia: A Preliminary Analysis. Available at: SSRN 3548758. 2020.

Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395:809-15.

Panahi L, Amiri M, Pouy S. Risks of Novel Coronavirus Disease (COVID-19) in Pregnancy; a Narrative Review. Arch Acad Emerg Med. 2020;8(1):e34.

Wang J, Qi H, Bao L, Li F, Shi Y. National Clinical Research Center for Child Health and Wang J, Qi H, Bao L, Li F, Shi Y. A contingency plan for the management of the 2019 novel coronavirus outbreak in neonatal intensive care units. Lancet Child & Adoles. Heal. 2020;4(4):258-9.

Caballero B, Méndez A, Caballero D. Varicella-zoster infection in the newborn: a case. Gaceta Médica de Bilbao. 2016;113(1):28-31.

Díaz A, Maestro L, Pumarega T, Antón F, Alonso R. Primer caso de infección neonatal por SARS-CoV-2 en España. In Anales De Pediatria 2020;92(4): 237.

Shek C, Ng C, Fung P, Cheng T, Chan S, Peiris S, et al. Infants born to mothers with severe acute respiratory syndrome. Pedia. 2003;112:e254.

Zeng H, Xu C, Fan J, Tang Y, Deng Q, Zhang W, et al. Antibodies in infants born to mothers with COVID-19 pneumonia. J American Med Asso. 2020.

Dong L, Tian J, He S, Zhu C, Wang J, Liu C, et al. Possible vertical transmission of SARSCoV-2 from an infected mother to her newborn. J American Med Asso. 2020.

Patanè L, Morotti D, Giunta R, Sigismondi C, Piccoli G, Frigerio L, et al. Vertical transmission of COVID-19: SARS-CoV-2 RNA on the fetal side of the placenta in pregnancies with COVID-19 positive mothers and neonates at birth. American J Obste Gyneco. 2020.

Kirtsman M, Diambomba Y, Poutanen M, Malinowski K, Vlachodimitropoulou E, Parkset T, et al. Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection. Canadian Med Asso J. 2020;192(24):647-50.

United Nations, Department of Economic and Social Affairs, Population Division (2019). World Population Prospects 2019, Online Edition.Rev. Available at: desa/population/index.asp Accessed on 7 May 2020.

Salud S. The weekly epidemiological report of pregnant and puerperal women studied, on suspicion of COVID-19. Available at: Accessed on 03 August 2020.

Penfield A, Brubaker G, Limaye A, Lighter J, Ratner A, Thomas M, et al. Detection of severe acute respiratory syndrome corona virus 2 in placental and fetal membrane samples. American J Obste Gyneco 2020;100133.

Vivanti A, Fellous V, Prevot S, Zupan V, Suffee C, Cao D, et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 2020;11:3572.