DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20204412

Clinical profile of dengue fever in children in a secondary care hospital: an observational study

R. Malai Arasu, P. Jagadeesan

Abstract


Background: Dengue is the most prevalent mosquito-borne viral disease worldwide. It is endemic to hyperendemic in various parts of India. Symptomatic dengue infection causes a wide range of clinical manifestations, from mild dengue fever to potentially fatal disease, such as dengue hemorrhagic fever or dengue shock syndrome. Aim of the study was to analyze the clinical profile of children affected by dengue fever.

Methods: A total of 250 who had dengue fever serologically positive cases had included in this study. All the demographic and clinical history and laboratory diagnosis had collected from the study people and written informed consent form had obtained from the patient. Results were statistically analyzed and discussed.

Results: Based on symptoms all the 250 patients had a fever, 219 patients had vomiting, 209 patients had a loss of appetite, 197 patients had abdominal pain, 160 patients had body/leg pain, 135 patients had a headache/ retro-orbital pain, 91 patients had abdominal distension, 81 patients had skin rashes, 53 patients had bleeding disorders, and 7 patients had a convulsion. 99 patients had an undifferentiated fever, 115 patients had dengue fever, and 43 patients had severe dengue fever. 75 patients had platelet count of 50,000-1,00,000/mm3, 34 patients had 20,000-50,000/mm3and 12 patients had less than 20,000/mm3 platelet count.

Conclusion: The majority had common presenting symptoms of fever, vomiting, headache and body pain. No deaths have occurred in this study. Conservative management strategy with rational platelet transfusion is effective in managing dengue patients.

 


Keywords


Dengue fever, Platelet, Hemorrhage, Headache

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References


Gregory CJ, Santiago LM, Arguello DF, Hunsperger E, Tomashek KM. Clinical and laboratory features that differentiate dengue from other febrile illnesses in an endemic area-Puerto Rico, 2007-2008. Am J Trop Med Hyg. 2010;82(5):922-9.

Kuo HJ, Lee IK, Liu JW. Analyses of clinical and laboratory characteristics of dengue adults at their hospital presentations based on the World Health Organization clinical phase framework: emphasizing the risk of severe dengue in the elderly. J Microbiol Immunol Infect. 2018;51:740-8.

World Health Organization. Dengue guidelines for diagnosis, treatment, prevention and control: new edition. Apps.who.int. 2009. Available at: https:// apps.who.int/iris/handle/10665/44188. Accessed on 3 October 2020.

Prommalikit O, Thisyakorn U. Dengue virus virulence and diseases severity. Southeast Asian J Trop Med Public Health. 2015;46(1):35-42.

Goncalvez AP, Engle RE, St Claire M, Purcell RH, Lai CJ. Monoclonal antibody-mediated enhancement of dengue virus infection in vitro and in vivo and strategies for prevention. Proc Natl Acad Sci USA. 2007;104:9422-7.

Mangione JN, Huy NT, Lan NT, Mbanefo EC, Ha TT, Bao LQ et al. The association of cytokines with severe dengue in children. Trop Med Health. 2014;42:137-44.

Van Gorp EC, Suharti C, Mairuhu AT, Dolmans WM, van Der Ven J, Demacker PN et al. Changes in the plasma lipid profile as a potential predictor of clinical outcome in dengue hemorrhagic fever. Clin Infect Dis. 2002;34:1150-3.

Falconar AK. The dengue virus nonstructural-1 protein (NS1) generates antibodies to common epitopes on human blood clotting, integrin/adhesin proteins and binds to human endothelial cells: potential implications in haemorrhagic fever pathogenesis. Arch Virol. 1997;142:897-916.

Zivna I, Green S, Vaughn DW, Kalayanarooj S, Stephens HA, Chandanayingyong D et al. T cell responses to an HLA-B)07 restricted epitope on the dengue NS3 protein correlate with disease severity. J Immunol. 2002;168:5959-65.

Thein TL, Ng EL, Yeang MS, Leo YS, Lye DC. Risk factors for concurrent bacteremia in adult patients with dengue. J Microbiol Immunol Infect. 2017;50:314-20.

Syue LS, Tang HJ, Hung YP, Chen PL, Li CW, Li MC et al. Bloodstream infections in hospitalized adults with dengue fever: clinical characteristics and recommended empirical therapy. J Microbiol Immunol Infect. 2019;52:225-32.

Mandal SK, Ganguly J, Sil K, Chatterjee S, Chatterjee K, Pankaj S et al. Clinical profiles of dengue fever in a teaching hospital of eastern India. National J Med Res. 2013;3(2):173-6.

Itoda I, Masuda G, Suganuma A, Imamura A, Ajisawa A, Yamada KI et al. Clinical features of 62 imported cases of dengue fever in Japan. Am J Tropical Med Hygiene. 2006;75(3):470-4.

Awasthi S, Singh VK, Kumar S, Kumar A, Dutta. The changing clinical spectrum of Dengue fever in the 2009 epidemic in north India: a tertiary teaching hospital-based study. J Clin Diagno Res. 2012;6(6):999-1002.

Karoli R, Fatima J, Siddiqi Z, Kazmi KA, Sultania AR. Clinical profile of dengue infection at a teaching hospital in North India. J Infection in Developing Countries. 2012;6(7):551-4.

Singh NP, Jhamb R, Agarwal SK, Gaiha M, Dewan R, Daga MK et al. The 2003 outbreak of dengue fever in Delhi, India. Southeast Asian J Tropical Med Public Health 2005;36(5):1174-8.

Tripathi BK, Gupta B, Sinha RSK, Prasad S, Sharma DK. Experience in the adult population in dengue outbreak in Delhi. J Asso Physicians of India. 1998;46(3):273-6.

Khan AH, Hayat AS, Masood N, Solangi NM, Shaikh TZ. Frequency and clinical presentation of dengue fever at tertiary care hospital of Hyderabad/Jamshoro. J Liaquat University of Med and Health Sci. 2010;9(2):88-94.

Horvath R, Mcbride WJH, Hanna JN. Clinical features of hospitalized patients during dengue three epidemics in Far North Queensland 1997-99. Dengue Bulletin. 1999;23:24-9.

Sharma S, Sharma SK. Clinical profile of DHF in adults during the 1996 outbreak in Delhi, India. Dengue Bulletin. 1998;22:20-7.

Chairulfatah A, Setiabudi D. Thrombocytopenia and platelet transfusions in DHF and DSS. Dengue Bulletin. 2003;27:138-43.