Blood glucose levels in children with acanthosis nigricans associated with obesity

Bonifacio Caballero- Noguez, Marco A. Cardoso-Gomez, María L. Ponce-Lopez, Antonio Mendez- Duran, Ulises Reyes- Gomez


Background: A body mass index ≥95 percentile increases 40 times the risk of diabetes. The hyperinsulinemia secondary to the resistance of insulin and obesity is associated to the development of acanthosis nigricans. The objective of current study was to associate acanthosis nigricans with childhood obesity with alterations in the curve of glucose tolerance.

Methods: In current study 90 children were evaluated with obesity and acanthosis nigricans of which only 34 concluded the study. Glucose, cholesterol and triglycerides levels were determined while in fasting state, and glucose tolerance curve was conducted. The statistical analysis was done by determining X², Fisher´s test and U, Mann Whitney test.

Results: Statistically significant difference was found between glucose levels at 2 hours and the presence of obesity and acanthosis nigricans (p<0.01).

Conclusions: It is important that all the children with obesity and Acanthosis nigricans apply for a curve of glucose tolerance.


Childhood obesity, Overweight, Acanthosis nigricans, Type 2 diabetes mellitus, Body mass index

Full Text:



Encuesta Nacional de Salud y Nutrición 2018. Available at: ensanut2018/doctos/informes/ensanut_2018_presentacion_resultados.pdf. Accessed on 24 September 2020.

Instituto Nacional de Salud Pública-Secretaría de Salud. Encuesta Nacional de Salud y Nutrición de Medio Camino 2016 (ENSANUT 2016), informe final de resultados. Available at: https://www.insp. mx/images/stories/2017/Avisos/docs/180315_encuesta_nacional_de_salud_y_nutricion_de_medio_Capdf.Accessed on 24 September 2020.

Kaufer-Horwits M, Perez-Lizaur AB, Arroyo P. Nutriología médica. 4th ed. México: DF Editorial Médica Panamericana SA; 2015.

Vega-Rodríguez P, Álvarez-Aguirre A, Bañuelos-Barrera Y, Reyes-Rocha B, Hernández Castañón MA. Lifestyle and nutritional status among school children. Enferm univ.2015;12(4):197-203.

Elizondo ML, Serrano MG, Ugalde CP, Cuello GC, Borbolla EJR. Metabolic syndrome risk factors among a sample of overweight and obese Mexican children. J Clin ypertense. 2010;12(5):380-7.

Ávila-Curiel A, Galindo-Gómez C, Juárez-Martínez L, Osorio-Victoria ML. Síndrome metabólico en niños de 6 a 12 años con obesidad, en escuelas públicas de siete municipios del Estado de México. Salud Publica Mex. 2018;60:395-403.

American Diabetes Association. 12. Children and adolescents: standards of medical care in diabetes-2018. Diabetes Care. 2018;41(Suppl 1):S126-36.

Genoni G, Menengon V, Secco G, Sonzini M, Martelli M, Castagno M, Insulin resistance, serum uric acid and metabolic syndrome are linked to cardiovascular dysfunction in pediatric obesity. Int J Cardiol. 2017;249:366-71.

Barrera-Cruz A, Rodríguez-González A, Molina-Ayala MA. Escenario actual de la obesidad en México. Rev Med Inst Mex Seguro Soc. 2013;51(3): 292-9.

Murillo Valles M, Bel Comós M. Obesidad y síndrome metabólico. Protoc diagn ter pediatr. 2019;1:285-94.

Zhu H, Zhang X, Li M, Xie J, Yang X. Prevalence of type 2 of diabetes and pre-diabetes among overweight or obese children in Tianjin, China. Diabetic Med. 2013;30(12):1457-65.

Slyper AH, Kashmer L, Huang W-M, Re’em Y. Acanthosis nigricans, vitamin D, and insulin resistance in obese children and adolescents. J Pediatr Endocrinol Metab. 2014;27(11-12):1107-11.

Yeste D, Carrascosa A. Obesity-related metabolic disorders in childhood and adolescence. Ann Pediatr. 2011;75(2):135.e1-9.

Weiss R, Caprio S. The metabolic consequences of childhood obesity. Best Pract Res Clin Endocrinol Metab. 2005;(19):405-19.

Rafalson L, Pham TH, Willi SM, Marcus M, Jessup A, Baranowski T. The association between acanthosis nigricans and dysglycemia in an ethnically diverse group of eighth grade students. Obesity (Silver Spring). 2013;21(3):E328-33.

Ordoñez M, Luzuriaga A, Flores M, Suquilanda D. Acanthosis nigricans as a practical diagnosis of endocrine diseases in pediatrics. Dermatol Rev Mex. 2019;63(1):3-7.