DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20210665

Common variable immunodeficiency disorder associated with bronchiectasis: a case report

Mohammad Zahirul Islam Khan, Kamrul Laila, Mohammed Mahbubul Islam, Mohammad Imnul Islam, Shahana Akhter Rahman

Abstract


Common variable immunodeficiency disorder (CVID) is the commonest type of primary immunodeficiency disorders (PIDs) characterized by hypogammaglobulinemia, defective specific antibody production and increased susceptibility of recurrent infections. Autoimmunity, neoplasm and lymphoproliferative disorders are usually associated with CVID. In most cases, the cause is unknown, but multiple gene mutations (10%) may be associated with CVID. Here, we report an eight years old girl with CVID presented with recurrent infections, growth failure, generalized lymphadenopathy and hepatosplenomegaly. Chest examination and radiological findings of this girl were consistent with bronchiectasis. Lack of awareness among health care providers is the reason for delayed diagnosis of several years for this girl. Therefore, it is essential to raise awareness regarding PID patients among the physicians to improve the quality of life.  


Keywords


CVID, Hypogammaglobulinemia, Recurrent infections

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