DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20210662

Mycoplasma pneumonia among children with acute respiratory infection

Anjali Ann Chacko, Ramaraj Subbiah, Tharun C. Varghese, Kundoly Velayudhan Susheela

Abstract


Background: Acute respiratory infection (ARI) is one of the leading causes of mortality and morbidity in children. Mycoplasma pneumonia remains the most common species causing ARI in school going children. IgM ELISA is considered as the single most appropriate test for diagnosis of acute mycoplasma pneumonia infection. Objectives of the study was to assess the proportion of mycoplasma pneumonia among children aged 2-12 years admitted with ARI using IgM ELISA kit.

Methods: Study design included prospective descriptive study. Study carried out at Amala institute of medical sciences, Thrissur, Kerala, India. Study period from January 2019 to June 2020. Inclusion criteria included all children between age group 2-12 years admitted in paediatrics department with clinical features of ARI. Exclusion criteria excluded parents/patients who are not willing to participate in the study and patients who are known cases of reactive airway disease. A total of 124 children, aged 2-12 years with clinical features of ARI admitted during January 2019 to June 2020 were included in this study. This was to know the proportion of Mycoplasma pneumonia among these children using IgM ELISA test kit and to understand their clinical profile.

Results: 71 were males. Mean age of children in the study group was 4.4±2.4. IgM ELISA was positive in 9 subjects (7.3%). Sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 50, 85, 40, 89.7 and 79.5% respectively.

Conclusions: Prevalence of Mycoplasma pneumonia in our population based on IgM ELISA was 7.3%. Mycoplasma pneumonia IgM ELISA test is superior to cold agglutinin test.


Keywords


Mycoplasma pneumonia, Respiratory tract infections, Immunoglobulin M

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References


Simoes EAF. Acute Respiratory Infections in Children. Disease Control Priorities in Developing Countries. 2nd edition. Washington (DC): The International Bank for Reconstruction and Development/The World Bank. Oxford University Press, New York. 2006;25.

Causes of death in neonates and children under five in the World: WHO. 2008. Available at: https://www.who.int/maternal_child_adolescent/media/CAH_causes_death_u5_neonates_2008.pdf. Accessed on 20 June 2020.

Nilanjan MK. A longitudinal study on ARI among rural under-fives. Indian J Comm Med. 2001;26:8-11.

Kliegma RM, St. Geme J. Nelson Text Book of Paediatrics, 21th Edn, Elsevier. 2019;250:1:1609-12.

Kashyap S, Sarkar M. Mycoplasma pneumonia: Clinical features and management. Lung India. 2010;27(2):75-85.

Win S, May WL, Aung WW, Win H. Mycoplasma pneumoniae Infection in Children with Acute Respiratory Infection. Myanmar Health Sci Res J. 2015;27:2.

Kashyap B, Kumar S, Sethi GR, Das BC, Saigal SR. Comparison of PCR, culture & serological tests for the diagnosis of Mycoplasma pneumoniae in community acquired lower respiratory tract infections in children. Indian J Med Res. 2008;128:134-9.

Huong PLT, Thi NT, Nguyet NTT. First report on clinical features of Mycoplasma pneumoniae infections in Vietnamese children. Japanese J Infect Dis. 2007;60:370-3.

Shenoy VD, Upadhyaya SA, Rao SP, Shobha KL. Mycoplasma pneumoniae infection in children with acute respiratory infection. J Trop Pediatr. 2005;51:232-5.

Waris ME, Toikka P, Saarinen T, Nikkari S. Diagnosis of Mycoplasma pneumoniae pneumonia in children. J Clin Microbiol. 1998;36:3155-9.

Elizabeth M, Padmavathy K, Cherian T, Inbamalar U, Sneha V. Brief reports. Indian Pediatr. 2001;38:157-60.