DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20213326

Kikuchi necrotizing lymphadenopathy: a tip of the iceberg disease?

Sushil Singla, Mohitesh Kumar, Vinod Kumar Jat, Deepika Parwan

Abstract


Kikuchi-Fujimoto disease (KFD) is a rare benign condition also called histiocytic necrotizing lymphadenitis, which typically presented as fever with cervical lymphadenopathy in previously healthy individual. We presented a case of 11 year old boy with fever and cervical lymphadenopathy since 2 months. Lymph node biopsy was performed which suggested of KFD and was treated symptomatically. KFD incidence is rare but clinicians should be alert if young patient comes with fever and cervical lymphadenopathy to lower the chance of unwanted laboratory test and harmful treatment. 


Keywords


Fever with lymphadenopathy, Kikuchi-Fujimoto disease, Histiocytic necrotizing lymphadenitis

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References


Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia. Nippon Ketsueki Gakkai Zasshi. 1972;35:378-80.

Fujimoto Y, Kozima Y, Yamaguchi K. Cervical subacute necrotizing lymphadenitis. A new clinicopathological agent. Naika. 1972;20:920-7.

Ramirez AL, Johnson J, Murr AH. Kikuchi Fujimoto’s disease: an easily misdiagnosed clinical entity. Otolaryngol Head Neck Surg. 2001;125(6):651-3.

Kuo T. Kikuchi’s disease (histiocytic necrotizing lymphadenitis): a clinicopathologic study of 79 cases with an analysis of histologic subtypes, immunohistology and DNA ploidy. Am J Surg Pathol. 1995;19(7):798-809.

Sudhakar MK, Sathyamurthy P, Indhumati E, Rajendran A, Vivek B. Kikuchi’s disease: a case report from South India. Int J Case Rep Image. 2011;2(1):15-8.

Bosch X, Guilabert A, Miquel R, Campo E. Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. Am J Clin Pathol. 2004;122(1):141-52.

Kuo T. Kikuchi’s disease (histiocytic necrotizing lymphadenitis): a clinicopathologic study of 79 cases with an analysis of histologic subtypes, immunohistology and DNA ploidy. Am J Surg Pathol. 1995;19(7):798-809.

Imamura M, Ueno H, Matsuura A, Kamiya H, Suzuki T, KKikuchi K, et al. An ultrastructural study of subacute necrotizing lymphadenitis. Am J Pathol. 1982;107(3):292-9.

Kapoor S. Rare complications of Kikuchi’s disease: beyond pain control. Korean J Pain. 2012;25(4):281-2.

Rivano MT, Falini B, Stein H, Canino S, Ciani C, Gerdes J, et al. Histiocytic necrotizing lymphadenitis without granulocytic infiltration (Kikuchi's lymphadenitis). Morphological and immunohistochemical study of eight cases. Histopathology. 1987;11:1013-27.