Alloimmunisation in Rh “c” negative mother causing severe fetal hemolysis

Authors

  • S. Pandu Ranga Rao Department of Transfusion Medicine, Nizam’s Institute of Medical Sciences, Hyderabad, India
  • Sudhir Kumar Vujhini Department of Transfusion Medicine, Nizam’s Institute of Medical Sciences, Hyderabad, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20150993

Keywords:

Alloimmunisation, Hemolytic disease of the newborn, Rh anti-c antibodies

Abstract

The most severe form of HDN is caused by Anti-D. Other common Rh antigens in the order of immunogenicity are c, E, C and e. Anti-c is the most important Rh antigen after the D antigen. We report a case of hemolytic disease of the newborn due to Rh anti-c in an infant of Rh c negative mother.

References

Dean L. Blood Groups and Red Cell Antigens. Bethesda (MD): National Center for Biotechnology Information (US), 2005. Chapter 4, Hemolytic disease of the newborn. Available from: http://www.ncbi.nlm.nih.gov/books/NBK2266/.

Negi G, Singh GD. Anti Rh Hemolytic Disease due to Anti C Antibody: Is Testing for Anti D Antibodies Enough? Indian Journal of Hematology & Blood Transfusion. 2012;28(2):121-2.

Singla S, Kumar S, Roy KK, Sharma JB, Kachhawa G. Severe hydrops in the infant of a Rhesus D-positive mother due to anti-c antibodies diagnosed antenatally: a case report. Journal of Medical Case Reports. 2010;4:57.

Thakral B, Agrawal SK, Dhawan HK, Saluja K, Dutta S, Marwaha N. First report from India of haemolytic disease of newborn by anti-c and anti-E in Rh (D) positive mothers. Hematology. 2007;12:377-80.

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Published

2017-01-04