Clinical profile and outcome of multisystem inflammatory syndrome in children in a tertiary care centre of North Kerala: a prospective study

Naveena Sajeevan, Mohammed Manakkatt T. P., Kavitha Pavithran, Urmila Muraleekrishnan K. V.


Multisystem inflammatory syndrome in children (MIS-C) is a newly emerged disease following the outbreak of COVID-19. The nomenclature is given by WHO. Similar condition is named as paediatric inflammatory multisystem syndrome-temporally associated with SARS-CoV2 virus (PIMS-TS), by RCPCH. To study the clinical profile and outcome of MIS-C in 2 months to 18 years old. The 25 children, admitted in PICU and pediatrics ward were included in the study. The 79% required PICU admission and two required mechanical ventilation. One child expired. Children presented with conjunctival congestion (53%), diarrhoea (47%), cervical lymphadenopathy (37%), shock (31.5%), vomiting (36.8%), rashes (36.8%), mucosal erythema (36.8%), cough (10.5%) and headache (10.5%). Inflammatory markers were elevated in all the children. On initial echocardiography, 4 children (21%) had LV dysfunction with LVEF <50%. Six children (31.5%) were treated with IVIG and IV methylprednisolone, changed to oral prednisolone after 3 days and continued for 2 weeks. Three children (18%) were treated with IVIG and oral prednisolone. Two children (12%) were treated with IVIG alone. Eight children (47%) were treated with methylprednisolone alone. The median duration of hospitalisation was 5 days. 18 children (94.7%) were discharged to home within one week of admission. One 8 months old baby presented with shock, succumbed to death in spite of giving IV methyl prednisolone and IVIG. In our study we observed that early diagnosis and treatment with IVIG or steroids offers good outcome for the condition. Of the 19 children studied, 17 children were discharged within one week.


Multisystem inflammatory syndrome, Intravenous immunoglobulin, Cytokine storm

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