Clinical profile of acute kidney injury in neonates with perinatal asphyxia

Revanasiddappa Bhosgi, Kirankumar Harwalkar


Background: Acute kidney injury (AKI) is one of the most common complication observed in perinatal asphyxia. Early recognition is required for appropriate treatment and improve the outcome.

Methods: It is a hospital based retrospective study conducted from august 2019 to December 2019. Total 85 full term neonates with perinatal asphyxia were included in the study. Renal functions were assessed by monitoring urine output, serum creatinine and ultrasonography. Acute kidney injury assessed by pRIFLE criteria and HIE staging is done by modified Sarnat and Sarnat staging. Severity of AKI is correlated with stages of HIE. AKI is managed as per unit protocol.

Results: Total 85 perinatal asphyxia neonates were included in the study. Out of total 85 neonates, 25 (29.4%) neonates had evidence of acute kidney injury. Among 25 neonates with acute kidney injury, higher percentage was observed in male neonates which was 14 (56%) against 11 (44%) among female neonates. Predominantly, non oligouric acute kidney injury was observed among acute kidney injury neonates which accounted to 20 neonates (80%) (p-0.258). Serum creatinine between 1.5-2 mg/dl was observed in 18 (21.1%) neonates and 7 (8.2%) neonates had creatinine between 2-3 mg/dl. Sonological abnormality was noted in 2 (2.3%) neonates. Among neonates with non oligouric AKI, 3 (12%) neonates had HIE stage 1, 15 (60%) had HIE-2 and 7 (28%) had HIE-3. However, neonates with non oligouric AKI were higher among HIE 2 when compared to neonates with oligouric renal failure who were higher in HIE 3. No mortality occurred among these neonates.

Conclusions: Majority of the neonates with perinatal asphyxia had non oliguric AKI which responded well to conservative treatment. AKI is most commonly seen in HIE stage 2 babies. Since non oligouric renal failure was a predominant finding among asphyxiated neonates, Serum creatinine monitoring remains main stay of diagnosis.



Perinatal asphyxia, AKI, Oliguria, Neonates, Hypoxic ischemic encephalopathy

Full Text:



Cowan F, Rutherford M, Goenedaal F, Murcuri E, Bydder GM. Origin and timing of brain lesions in term infants with neonatal encephalopathy. Lancet. 2003;361:736-42.

Grow J, Barks JD. Pathogenesis of hypoxic ischemic brain injury in the term infant- current concepts. Perinat. 2004;29:585-602.

Cloherty JP, Eichenwald EC, Stark AR. Manual of neonatal care. 7th ed. Philadelphia,PA: Lippincot Williams and Wilkins. 2011;711-8.

Akcan A, Zappitelli M, Loftiz LL, Washbum KK, Jellerson LZ. Modified RIFLE criteria including children with Acute kidney injury. J Nephrol. 2001;71:1028-33.

Sarnat, Sarnat. Neonatal encephalopathy following fetal distress. Arch neurol. 1976;33:696-705.

Vanpee M, Blennow M, Linne T, Herin P, Aperia A. Renal function in very low birth weight infants: normal maturity reached during early childhood. J Pediatr. 1992;121:784-8.

Durkan AM, Alexander RT. Acute injury post neonatal asphyxia. J Pediatr. 2011;158(2):e29-33.

Anne M Durkan, Todd Alexander R. Acute kidney injury post neonatal asphyxia. J Pediatr 2011;158(2):e29-e33.

Aggarwal A, Kumar P, Chowdary G, Majumdar S, Narang A. Evaluation of renal functions in asphyxiated neonates. J Trop Pediatr. 2005;51(5):295-9.

Girish G. Acute kidney injury (AKI) in perinatal asphyxia. Indian J Pharm Boil Res. 2014;2(2):60-5.

Medani SA, Kheir AEM, Mohamed MB. Acute kidney injury in asphyxiated neonates admitted to a tertiary neonatal unit in sudan. Sudan J Pediatr. 2014;14(2):29-34.

Alaro D, Bashir A, Musoke R, Wanaiana L. Prevalence and outcomes of acute kidney injury in term neonates with perinatal asphyxia. African health sciences. 2014;14(3),682-8.

Agrawal S, Chaudhuri PK, Chaudhary AK, Kumar D. Acute kidney injury in asphyxiated neonates and its correlation hypoxic ischemic encephalopathy staging. Indian J Child Health. 2016;3(3):254-7.

Gupta BD, Sharma P, Bagla J, Parakh M, Soni JP. Renal failure in asphyxiated neonates. Indian pediatrics. 2005;42(9):928-34.