A comparative study of the transfusion effect of single donor apheresis platelets versus random donor platelets in the management of severe dengue infection in children

Authors

  • Chandra Deve Varma B. S. K. Buddharaju Department of Pediatrics, Maharajah’s Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India
  • Gujjarlamudi Chandrakanth Department of Pediatrics, Maharajah’s Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India
  • Konala Venkata Shiva Reddy Department of Pediatrics, Maharajah’s Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India
  • Vundela Lokeswara Reddy Department of Pediatrics, Maharajah’s Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India
  • Lambadi Shanmukha Som Department of Pediatrics, Maharajah’s Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20221380

Keywords:

Apheresis, Compatible, Homeostasis, Leukoreduction, Platelet concentrate

Abstract

Background:  The national vector-borne diseases control programme (NVBDCP) dengue clinical care guidelines 2014 clearly specify the indications for platelet transfusion in dengue fever. The goal of the study was to see how successful guideline-driven platelet transfusion was, as well as whether single donor platelet (SDP) transfusion was superior to random donor platelet transfusion (RDP), which was widely thought but unproven.

Methods: Two ml of the patient's blood were collected in EDTA tubes at two distinct times: once before the transfusion and the other 24 hours afterwards and the data were assessed using corrected count increments (CCI), percentage recovery (PR) and other criteria.

Results: Platelet increments were substantially larger with SDP transfusions at 24 hours than with RDP transfusions (p<0.01 for 24 hours post-transfusion period). However, in both groups, the corrected count increment and percentage recovery were nearly identical and the difference was statistically insignificant.

Conclusions: Although post-transfusion increments were considerably higher in SDP patients than in RDP patients, the CCI and PR were similar in both groups of patients. When it comes to the number of donors exposed to patient and leukoreduction, SDP is superior to RDP in terms of logistics. However, in developing countries, SDP may be advised only in selected patients based on accessibility and affordability, due to their high cost and higher technical competence required.

Author Biographies

Chandra Deve Varma B. S. K. Buddharaju, Department of Pediatrics, Maharajah’s Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India

Department of pediatrics, ASSOCIATE PROFESSOR 

Gujjarlamudi Chandrakanth, Department of Pediatrics, Maharajah’s Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India

Jr resident, pediatrics

Konala Venkata Shiva Reddy, Department of Pediatrics, Maharajah’s Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India

Jr resident , pediatrics

Vundela Lokeswara Reddy, Department of Pediatrics, Maharajah’s Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India

Jr resident, pediatrics

Lambadi Shanmukha Som, Department of Pediatrics, Maharajah’s Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India

Jr resident, pediatrics

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Published

2022-05-25

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Original Research Articles