Clinical profile and outcome in neonates born to COVID-19 positive mothers and COVID positive children aged between 1 month to 12 years admitted in a tertiary COVID care centre: a cross sectional study

Madhavi N., Madan M. Mohan, Jhansi K. Padma, Venkata V. Vijayalakshmi


Background: COVID-19 pandemic has caused worldwide havoc since the first case was discovered in China in December 2019. The infection has caused less severe infections and fewer deaths in children compared to adults. During the first two waves of COVID-19, the mortality rate in children has been <3% in India though more severe infections and hospitalizations were seen during the second wave. This study was undertaken at a tertiary Pediatric COVID care center during the third wave to understand the clinical, morbidity profile and outcomes in neonates born to COVID positive mothers and children who are COVID positive.

Methods: Neonates born to COVID positive mothers and children between the age group 1 month to 12 years admitted in Government general hospital, Kakinada, Andhra Pradesh from 1January 2022 to 31March 2022 were included in the study. Their demographic, clinical, morbidity profile, treatment details were noted and outcomes observed.

Results: All neonates were found to be RTPCR negative. 28% of neonates were born prematurely and 16% had birth asphyxia. Respiratory distress was the most presenting symptom. Death was seen in 4 newborns due to perinatal complications. More children less than 10 years required admission.15% of children were asymptomatic. Fever, cough, and running nose were the most presenting complaints. 2 children who had co-morbidities at the time of admission died.

Conclusions: The third wave of COVID-19 did not cause any significant change in morbidity and mortality in children compared to the previous two waves.



COVID-19, Neonates, Children, Respiratory distress, Fever

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Kasi SG, Dhir SK, Shah A, Shivananda S, Verma S, Marathe S, et al. Coronavirus Disease 2019 (COVID-19) vaccination for children: position statement of indian academy of pediatrics advisory committee on vaccination and immunization practices. Indian Pediatr. 2022;59(1):51-7.

UNICEF COVID data. Available at: https://data. Accessed on 20 November 2021.

Vivanti AJ, Vauloup-Fellous C, Prevot S, Zupan V, Suffee C, Do Cao J, et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 2020;11(1): 3572.

Zeng L, Xia S, Yuan W, Yan K, Xiao F, Shao J, et al. Neonatal early-onset infection with sars-cov-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China. JAMA Pediatr. 2020;174(7):722-5.

Dong L, Tian J, He S, Zhu C, Wang J, Liu C, et al. Possible vertical transmission of sars-cov-2 from an infected mother to her newborn. JAMA. 2020; 323(18): 1846-8.

Salvatore CM, Han JY, Acker KP, Tiwari P, Jin J, Brandler M, et al. Neonatal management and outcomes during the COVID-19 pandemic: an observational cohort study. Lancet Child Adolesc Health. 2020;4(10):721-7.

Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395(10226):809-15.

Nanavati R, Mascarenhas D, Goyal M, Haribalakrishna A, Nataraj G. A single-center observational study on clinical features and outcomes of 21 SARS-CoV-2-infected neonates from India. Eur J Pediatr. 2021;180(6):1895-906.

Anand P, Yadav A, Debata P, Bachani S, Gupta N, Gera R. Clinical profile, viral load, management and outcome of neonates born to COVID 19 positive mothers: a tertiary care center experience from India. Eur J Pediatr. 2021;180(2):547-59.

Kotlyar AM, Grechukhina O, Chen A, Popkhadze S, Grimshaw A, et al. Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis. Am J Obstet Gynecol. 2021;224(1):35-53.

Ferrazzi E, Frigerio L, Savasi V, Vergani P, Prefumo F, Barresi S, et al. Vaginal delivery in SARS-CoV-2 infected pregnant women in Northern Italy: a retrospective analysis. BJOG. 2020;127(9):1116-21.

Kumar P, More K, Chawla D, Murki S, Tandur B, Deorari, et al. Outcomes of neonates born to mothers with coronavirus disease 2019 (COVID-19)-National neonatology forum (NNF) India COVID-19 Registry. Indian Pediatr. 2021;58(6):525-31.

Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. Epidemiology of COVID-19 among children in China. Pediatrics. 2020;145(6):34-9.

Götzinger F, Santiago-García B, Noguera-Julián A, Lanaspa M, Lancella Let al. COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study. Lancet Child Adolesc Health. 2020;4(9):653-61.

Borrelli M, Corcione A, Castellano F, Fiori Nastro F, Santamaria F. Coronavirus disease 2019 in children. Front Pediatr. 2021;9:481.

Majhi MM, Borle AL, Lal P, Meena M, Ramani KV. Vaccination with routine childhood vaccines and severity of COVID-19 among children in Delhi. Indian Pediatr. 2022;59(2):132-4.