Published: 2022-11-24

Clinical profile and outcome of Guillain Barre syndrome in a tertiary care hospital

Sravya Sree Sreekantham, Sudha Rudrappa, Thanuja Basauanagowsa


Background: Guillain Barre syndrome (GBS) is a progressive symmetric muscular weakness with absent or depressed deep tendon reflexes. Wide spectrum of disease severity can be seen ranging from a mild disease to quadriparesis, cranial nerve involvement and autonomic instability.

Methods: Hospital based observational study is planned for GBS patients admitted to Cheluvamba hospital, a tertiary care hospital in South India, for a period of 2.5 years from Jan 2020 to August 2022.

Results: 30 patients (12 males; 18 females; mean age of 7.7 years) were enrolled in this study. Among which 11 were in age group of 0-5 (36%), 10 were in the age group of 6-10 (33%), 7 were in age group of 10-15 (23%), 2 were in age group 16 and above (6.6%). Type of paralysis was paraparesis in 14 (46%) children quadriparesis in 15 (50%) children and one child had no limb involvement. In associated dysfunctions, autonomic dysfunction was seen in 1 (4.5%), bulbar palsy in 3 (13.6%). One child presented with features of Miller Fischer variant of GBS which are ophthalmoplegia and ataxia. Among 30 children 22 were recovered and discharged, 3 children died, and 5 children left against medical advice.

Conclusions: The clinical characteristics, subtype of GBS, and outcome vary according to geographic area. This study is directed to find the clinical pattern and outcome of the same in tertiary care hospital in south India.


Intravenous immunoglobulin, Plasmapheresis, Acute flaccid paralysis

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Rangan RS, Tullu MS, Deshmukh CT, Mondkar SA, Agrawal M. Clinical Profile and Outcome of Guillain-Barre Syndrome in Pediatric Patients Admitted to a Tertiary Care Centre: A Retrospective Study. Neurol India. 2021;69(1):81-4.

Meshram RM, Bokade CM, Merchant S, Abhisheik S, Agrawal H, Dhakne S. Clinical profile of childhood Guillain-Barre Syndrome. Int J Pediatr Res. 2016;3(6):427-32.

Khairani AF, Karina M, Siswanti LH, Dewi MM. Clinical Profile of Pediatric Guillain-Barré Syndrome: A study from National Referral Hospital in West Java, Indonesia. Biomed Pharmacol J. 2019;12(4).

Momen AA, Shakurnia A. The Epidemiology of Guillain-Barré Syndrome in Children under 15 Years Old in Southwest Iran. Biomed Hub. 2017;2:1-8.

Bhagat SK, Sidhant S, Bhatta M, Ghimire A, Shah B. Clinical Profile, Functional Outcome, and Mortality of Guillain-Barre Syndrome: A Five-Year Tertiary Care Experience from Nepal. Neurol Res Int. 2019;2019:3867946.

Salehiomran MR, Nikkhah A, Mahdavi M. Prognosis of Guillain-Barré Syndrome in Children. Iran J Child Neurol. 2016;10(2):38-41.

Sonali S, Nitin G, Arpita GM, Anurag C, Sneha W, Pallavi S. Clinical profile and predictors for outcome in children presenting with Guillain-Barré syndrome. J Family Med Primary Care. 2020;9(10):5316-9.

Kollár K, Liptai Z, Rosdy B, Móser J. Guillain-Barré-szindróma gyermekkorban [Guillain-Barré syndrome in childhood]. Ideggyogy Sz. 2009;62(11-12):399-404.

Koul R, Al-Futaisi A, Chacko A, Fazalullah M, Nabhani SA, Al-Awaidy S et al. Clinical characteristics of childhood Guillain-Barre syndrome. Oman Med J. 2008;23(3):158-61.

Roodbol J, De Wit MY, Van den Berg B, Kahlmann V, Drenthen J, Catsman-Berrevoets CE et al. Diagnosis of Guillain-Barré syndrome in children and validation of the Brighton criteria. J Neurol. 2017;264(5):856-61.