DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20221613

Incidence of hepatitis A in children with acute icteric hepatitis of district Shopian of Kashmir

Rais Ahmad Lone, Ishfaq Khurshid, Azhar Mushtaq

Abstract


Background: Viral hepatitis is a major health problem worldwide. It is caused by at least five hepatotropic viruses, hepatitis A virus being the commonest one. The virus is responsible for most forms of acute benign hepatitis, although fulminant hepatic failure can occur. HAV spreads mainly through the fecal-oral route and hence is preventable by precautionary methods. Hepatitis A vaccine is available and highly effective in preventing disease. Objective of current study was to find the incidence of hepatitis A in children with features of acute icteric hepatitis of district Shopian of Kashmir.

Methods: We sampled 83 children aged above 1 year to 17 years who attended the hospital for different features suggestive of hepatitis and evaluated them after proper and detailed history followed by relevant investigations and serology. Cases were labelled positive or negative on the basis of HAV IgM antibody.

Results: We had 83 cases, 36 were boys (43.37%) and 47 were girls (56.62%). The girls made just more than a half of the cases and the boys just below half the cases. 13.25% (11 cases) were aged 1 to 4 years (none was below 2 years), 32.53% (27) were 4 to 7years, 32.53% (27) were 7 to 10 years, 16.87% (14) were 10 to 13 years, only 4.82% (4 cases) reported were 13 to 17 years. All 83 proved to be hepatitis A (100%).

Conclusions: This study found that the incidence of hepatitis A in children with features of acute icteric hepatitis is very high in the children of district Shopian & a survey with a very large sample size will be ideal.


Keywords


Hepatitis, Hepatitis A Virus, Hepatotropic, Icterus, Serology, Fulminant, Antibody

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References


Salahuddin M, Syed S A, Manzoor H, Mahenaz A, Farhana T. Recent spectrum of acute viral hepatitis in children: an experience in a tertiary centre of Bangladesh. Adv Res Gastroentero Hepatol. 2017; 6(3):555-686.

Girish N. A clinical study of viral hepatitis in children: a prospective hospital based study. Int J Contemp Pediatr. 2018;5(2):563-8.

Jensen MK, Balistreri WF. Nelson Textbook of Pediatrics. 20th ed. United States of America: Springer; 1998.

Kozak RA. Development and evaluation of a molecular hepatitis A virus assay for serum and stool specimens. Viruses. 2022;14(1):159.

Matheny SC, Kingery JE. Hepatitis A. Am Fam Physician. 2012;86(11):1027-34.

Escobedo-Meléndez G. Prevalence of hepatitis A, B and C serological markers in children from western Mexico. Ann Hepatol. 2012;11(2):194-201.

Michaelis K. Hepatitis A virus infections, immunizations and demographic determinants in children and adolescents, Germany. Sci Rep. 2018; 8:166-9.

Pirinççioğlu AG, Adıgüzel S, Özekinci T. Seropositivity of Hepatitis A in Children Aged 7-14 Years in Diyarbakir Province Center. Med Sci Monit. 2018;24:936-43.

Gupta R. A study of hepatitis A virus seropositivity among children aged between 1 and 5 years of age: Implications for universal immunization. Med J Armed Forces India. 2019;75(3):335-8.

Matheny SC, Kingery JE. Hepatitis A. Am Fam Physic. 2012;86(11):1027-34.

Özekinci T. Hepatitis A virus infections, immunisations and demographic determinants in children and adolescents, Germany. Sci Rep. 2018;8: 16696.

Arankalle V. Changing epidemiology of hepatitis A virus in Indian children. Vaccine Develop Ther. 2014; 4:7-13.

Averhoff F, Shapiro CN, Bell BP. Control of hepatitis a through routine vaccination of children. JAMA. 2001;286(23):2968-73.

Behera MR, Patnaik L. Clinico-biochemical profile and etiology of acute viral hepatitis in hospitalized children: A study from Eastern India. Indian J Child Health. 2003;4:317-20.

Rasheed J, Khalid M, Rubab S. Clinical and epidemiological spectrum of acute viral hepatitis due to hepatitis A and E in Children: a descriptive, cross-sectional, hospital-based study. Cureus. 2014;4: e24056.

Walsey A, Bell BP. Hepatitis A in the era of vaccination. Epidimiol Rev. 2006;28:101-11.

Franco E. Hepatitis A: epidemiology and prevention in developing countries. World J Hepaol. 2012;4(3): 68-73.