Association of biophysical profile with neonatal outcome: an observational study

Gurmeet Singh, Reena Sood, Karandeep Kaur


Background: Perinatal asphyxia is a common cause of neonatal mortality and morbidity in India. Antenatal surveillance prevents foetal injury and death and improves long term neurological outcome through optimal timing of delivery while avoiding unnecessary interventions such as caesarean delivery or preterm delivery.

Methods: After thorough history and physical examination, all patients underwent BPP assessment with USG and electronic foetal heart rate tracing and association between BPP score and various parameters were studied.

Results: Low BPP scores were associated with low Apgar score, increased rate of neonatal admissions and increased neonatal deaths. For BPP score of 6 there were 5 deaths constituting 71.4% of the total cases.

Conclusions: BPP score was found to be significantly associated with Apgar score and neonatal outcomes.


Apgar score, Biophysical profile, Foetal hypoxia, Neonatal outcome

Full Text:



Lawn JE, Kerber K, Laryea EC, Cousens S, Stst DM. 3.6 million neonatal deaths- what is progressing and what is not? Semin Perinatol. 2010;34:371-86.

ACOG Guidelines on antepartum fetal surveillance. Am Fam Physician. 2000;62(5):1184-8.

Turan S, Miller J, Baschat AA. Integrated testing and management in foetal growth restriction. Semin Perinatol. 2008;32(3):194-200.

Vintzileos AM, Campbell WA, Rodis JF. Foetal biophysical profile scoring: current status. Clin Perinatol. 1998;16(3):661-89.

Filho HA, Junior AE, Nardozza LM, Costa LL, Moron AF, Mattar R. Ultrasound assessement of the fetal biophysical profile: what does an radiologist need to know? Eur J Radiol. 2008;66(1):122-6.

Lalor JG, Fawole B, Alfirevic Z, Devane D. Biophysical profile for fetal assessment in high risk pregnancies. Cochrane Database Syst Rev. 2008;23:CD000038.

Alfirevic Z, Neilson JP. Biophysical profile for fetal assessment in high risk pregnancies. Cochrane Database Syst Rev. 2000;2:CD000038.

Filho GHA, Araujo E, Nardozza LM, Costa DLL, Moron AF, Mattar R. Ultrasound assessment of the fetal biophysical profile: what does a radiologist need to know? Eur J Radiol. 2008;66:122-6.

FA Manning. Fetal biophysical profile score theoretical considerations and practical application. Sonography in obstetrics and gynecology principle. Chapter 32, 7th/Edition, The McGraw-Hill compnies China; 2011.

Baschat AA, Viscardi RM, Gardner BH. Infant neurodevelopment following fetal growth restriction: relationship with antepartum surveillance paramteres. Ultrasound Obstet Gynecol. 2009;33:44-50.

Baschat AA, Galan HL, Bhide A, Berq C, Kush ML, Oepkes D, et al. Doppler and biophysical assessment in growth restricted fetuses. Ultrasound Obstet Gynecol. 2006;27:41-7.

Lin CC, Adamczyk CJ, Mittendiorf R. Fetal congenital malformations biophysical profile evaluation. J Reprod Med. 1998;43(6):521-7.

Arauz RJF, Chequer MJC, Lopez AAG, Hernandez JVH, Mendez AJA. Usefulness of biophysical profile in preterm rupture of membranes with treatment. Gynecol Obstet Mex. 2005;73:415-23.

Manning FA, Morrison I, Lange IR, Harman CR, Chamberlain PF. Fetal assessment based on fetal biophysical profile scoring: experience in 12,620 referred high-risk pregnancies, perinatal mortality by frequency and etiology. Am J Obstet Gynecol. 1985;151(3):343-50.

Manning FA. The fetal biophysical profile score: current status. Obstet Gynecol Clin North Am 1990 Mar;17 (1):147-62.

Manning FA, Harman CR, Menticoglou S, Morrison I. Assessment of fetal well being with ultrasound. Obstet gynecol Clin North Am. 1991 Dec;18(4): 891-905.

Manning FA. Fetal biophysical profile: a critical appraisal. Clin Obstet Gynecol. 2002;45(4):975-85.

Albu AR, Horhoianu IA, Dumitrascu MC, Horhoianu V. Growth assessment in diagnosis of fetal growth restriction. J Med Life. 2014;7(2):150-4.

Bano B, Zahid B. Hussain U. Fetal biophysical profile, as a tool to predict fetal outcome. Perinatal Med J. 2010;17(4):670-5.

Shah DM, Brown JE, Salyer SL, Fleischer AC, Boehm FH. Modified scheme for biophysical profile scoring. Am J Obstet Gynecol. 1989;160(3):586-91.

Mahmoud G, Tasnim N, Qazi A. Admission biophysical profile a better predictor of perinatal out come mother and child health centre, Pakistan Institute of Medical Sciences Islamabad. J Surg Pak. 2000;16:6-11.